DegronMD

Uniprot ID: Q8TF74

Source protein: WAS/WASL-interacting protein family member 2

Source gene: WIPF2

Class: DEG_APCC_TPR_1

Location: 438:440

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9214

ASA_SCORE: 143.8333

COIL: 0.9533

CONS_SCORE: 0.608

DSS_SCORE: 0.9236

HELIX: 0.03

FCONS_SCORE: 1.0235

RIG_SCORE: 0.7501

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L439F	TCGA-EE-A29L	SKCM	TCGA	ILR	DEG_APCC_TPR_1	0.6981
p.P437S	TCGA-61-1728	OV	TCGA	ILR	DEG_APCC_TPR_1	0.3056
p.P436Q	TCGA-CD-8529	STAD	TCGA	ILR	DEG_APCC_TPR_1	0.2778
p.P434H	SIDM00487	Colorectal Carcinoma	GDSC	ILR	DEG_APCC_TPR_1	0.2222
p.P434H	ACH-000963	Colon/Colorectal Cancer	CCLE	ILR	DEG_APCC_TPR_1	0.2222
p.P434H	CCK-81	large_intestine	COSMIC	ILR	DEG_APCC_TPR_1	0.2222
p.R430S	TCGA-AA-A01P	COAD	TCGA	ILR	DEG_APCC_TPR_1	0.1111
p.R430H	SIDM00203	Ewing's Sarcoma	GDSC	ILR	DEG_APCC_TPR_1	0.1111
p.R430H	ACH-002111	Bone Cancer	CCLE	ILR	DEG_APCC_TPR_1	0.1111
p.R430H	EW-11	bone	COSMIC	ILR	DEG_APCC_TPR_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF74	WAS/WASL-interacting protein family member 2	DEG_APCC_TPR_1	438:440	ILR	APC,CDC20,FZR1	0.9214	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons