DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DDFESKYSFHP
Uniprot ID:
Q8TF74
Source protein:
WAS/WASL-interacting protein family member 2
Source gene:
WIPF2
Class:
CBL_PTK
Location:
394:404
E3 ligase:
CBL
DEGRON score:
0.9948
ASA_SCORE:
60.7818
COIL:
0.6933
CONS_SCORE:
0.5183
DSS_SCORE:
0.402
HELIX:
0.1645
FCONS_SCORE:
1.0733
RIG_SCORE:
0.7457
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D407G
TCGA-CM-5341
COAD
TCGA
DDFESKYSFHP
CBL_PTK
0.25
p.K399N
TCGA-CV-6952
HNSC
TCGA
DDFESKYSFHP
CBL_PTK
0.5806
p.V405I
TCGA-D7-6822
STAD
TCGA
DDFESKYSFHP
CBL_PTK
0.3056
p.D394Y
TCGA-OR-A5KB
ACC
TCGA
DDFESKYSFHP
CBL_PTK
0.7325
p.Y414C
TCGA-P3-A6SX
HNSC
TCGA
DDFESKYSFHP
CBL_PTK
0.5
p.D394N
TCGA-QS-A5YR
UCEC
TCGA
DDFESKYSFHP
CBL_PTK
0.5821
p.S385C
SIDM00789
Colorectal Carcinoma
GDSC
DDFESKYSFHP
CBL_PTK
0.5278
p.S385C
ACH-000997
Colon/Colorectal Cancer
CCLE
DDFESKYSFHP
CBL_PTK
0.5278
p.S385C
ACH-001061
Colon/Colorectal Cancer
CCLE
DDFESKYSFHP
CBL_PTK
0.5278
p.S385C
HCT-15
large_intestine
COSMIC
DDFESKYSFHP
CBL_PTK
0.5278
p.D395H
ACH-000033
Lung Cancer
CCLE
DDFESKYSFHP
CBL_PTK
0.6577
Drug responses associated with WIPF2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DDFESKYSFHP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TF74
WAS/WASL-interacting protein family member 2
CBL_PTK
394:404
DDFESKYSFHP
CBL
0.9948
More...
