DegronMD - O75151(PHF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E923D	TCGA-55-8511	LUAD	TCGA	SPTARVGPS	DEG_SIAH_1	905:913	Mutation rewiring degron network	0.0556
p.P993L	TCGA-AA-3947	COAD	TCGA	PASTS	DEG_SPOP_SBC_1	993:997	Mutation altering degron motif	0.7582
p.R922C	TCGA-AA-A01R	COAD	TCGA	SPTARVGPS	DEG_SIAH_1	905:913	Mutation rewiring degron network	0.0833
p.R896M	TCGA-BR-4363	STAD	TCGA	SPTARVGPS	DEG_SIAH_1	905:913	Mutation rewiring degron network	0.0833
p.T493A	TCGA-CD-A4MG	STAD	TCGA	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.0556
p.T493A	TCGA-HU-A4H8	STAD	TCGA	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.0556
p.T493A	TCGA-L5-A4OI	ESCA	TCGA	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.0556
p.T493A	DO48009	STAD	ICGC	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.0556
p.T493A	DO47869	STAD	ICGC	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.0556
p.P480T	TCGA-CH-5739	PRAD	TCGA	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.7031
p.P480T	DO36304	PRAD	ICGC	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.7031
p.P903S	TCGA-EE-A20C	SKCM	TCGA	SPTARVGPS	DEG_SIAH_1	905:913	Mutation rewiring degron network	0.2778
p.P903L	TCGA-EE-A20C	SKCM	TCGA	SPTARVGPS	DEG_SIAH_1	905:913	Mutation rewiring degron network	0.2778
p.P906Q	TCGA-EE-A2GI	SKCM	TCGA	SPTARVGPS	DEG_SIAH_1	905:913	Mutation altering degron motif	0.7035
p.S474F	TCGA-ER-A19W	SKCM	TCGA	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation blocking phosphorylation signal	0.7222
p.S474F	DO50300	SKCM	ICGC	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation blocking phosphorylation signal	0.7222
p.A999T	TCGA-EY-A5W2	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	988:992	Mutation rewiring degron network	0.1389
p.A999T	TCGA-EY-A5W2	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	993:997	Mutation rewiring degron network	0.2778
p.A999T	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	988:992	Mutation rewiring degron network	0.1389
p.A999T	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	993:997	Mutation rewiring degron network	0.2778
p.A999T	ACH-000904	Lung Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	988:992	Mutation rewiring degron network	0.1389
p.A999T	ACH-000904	Lung Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	993:997	Mutation rewiring degron network	0.2778
p.R919S	SIDM02039	Colorectal Carcinoma	GDSC	SPTARVGPS	DEG_SIAH_1	905:913	Mutation rewiring degron network	0.1667
p.A989T	SIDM01307	Colorectal Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	988:992	Mutation altering degron motif	0.6028
p.A974V	SIDM00214	Colorectal Carcinoma	GDSC	AGTTS	DEG_SPOP_SBC_1	974:978	Mutation altering degron motif	0.5825
p.A974V	ACH-000955	Colon/Colorectal Cancer	CCLE	AGTTS	DEG_SPOP_SBC_1	974:978	Mutation altering degron motif	0.5825
p.A478V	SIDM00537	Colorectal Carcinoma	GDSC	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.5825
p.A478V	ACH-000982	Colon/Colorectal Cancer	CCLE	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.5825
p.A478V	ACH-001345	Colon/Colorectal Cancer	CCLE	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.5825
p.A478V	GP5d	large intestine	COSMIC	IEATPPQS	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.5825
p.A902T	SIDM01721	Non-Cancerous	GDSC	SPTARVGPS	DEG_SIAH_1	905:913	Mutation rewiring degron network	0.25
p.A902T	SIDM00191	Kidney Carcinoma	GDSC	SPTARVGPS	DEG_SIAH_1	905:913	Mutation rewiring degron network	0.25

Kaplan plot for PHF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHF2

UniProt ID: O75151

Entrez ID: 5253

Protein name: Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHF2 in