DegronMD

Uniprot ID: O75151

Source protein: Lysine-specific demethylase PHF2

Source gene: PHF2

Class: DEG_SCF_FBW7_1

Location: 476:483

E3 ligase: FBXW7

DEGRON score: 0.7213

ASA_SCORE: 86.0375

COIL: 0.8143

CONS_SCORE: 0.3082

DSS_SCORE: 0.7478

HELIX: 0.1548

FCONS_SCORE: 0.958

RIG_SCORE: 0.6333

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T493A	TCGA-CD-A4MG	STAD	TCGA	IEATPPQS	DEG_SCF_FBW7_1	0.0556
p.T493A	TCGA-HU-A4H8	STAD	TCGA	IEATPPQS	DEG_SCF_FBW7_1	0.0556
p.T493A	TCGA-L5-A4OI	ESCA	TCGA	IEATPPQS	DEG_SCF_FBW7_1	0.0556
p.T493A	DO48009	STAD	ICGC	IEATPPQS	DEG_SCF_FBW7_1	0.0556
p.T493A	DO47869	STAD	ICGC	IEATPPQS	DEG_SCF_FBW7_1	0.0556
p.P480T	TCGA-CH-5739	PRAD	TCGA	IEATPPQS	DEG_SCF_FBW7_1	0.7031
p.P480T	DO36304	PRAD	ICGC	IEATPPQS	DEG_SCF_FBW7_1	0.7031
p.S474F	TCGA-ER-A19W	SKCM	TCGA	IEATPPQS	DEG_SCF_FBW7_1	0.7222
p.S474F	DO50300	SKCM	ICGC	IEATPPQS	DEG_SCF_FBW7_1	0.7222
p.A478V	SIDM00537	Colorectal Carcinoma	GDSC	IEATPPQS	DEG_SCF_FBW7_1	0.5825
p.A478V	ACH-000982	Colon/Colorectal Cancer	CCLE	IEATPPQS	DEG_SCF_FBW7_1	0.5825
p.A478V	ACH-001345	Colon/Colorectal Cancer	CCLE	IEATPPQS	DEG_SCF_FBW7_1	0.5825
p.A478V	GP5d	large_intestine	COSMIC	IEATPPQS	DEG_SCF_FBW7_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SCF_FBW7_1	476:483	IEATPPQS	FBXW7	0.7213	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons