DegronMD

Uniprot ID: O75151

Source protein: Lysine-specific demethylase PHF2

Source gene: PHF2

Class: DEG_SIAH_1

Location: 905:913

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9833

ASA_SCORE: 73.9

COIL: 0.8994

CONS_SCORE: 0.3287

DSS_SCORE: 0.7127

HELIX: 0.068

FCONS_SCORE: 0.9808

RIG_SCORE: 0.6259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E923D	TCGA-55-8511	LUAD	TCGA	SPTARVGPS	DEG_SIAH_1	0.0556
p.R922C	TCGA-AA-A01R	COAD	TCGA	SPTARVGPS	DEG_SIAH_1	0.0833
p.R896M	TCGA-BR-4363	STAD	TCGA	SPTARVGPS	DEG_SIAH_1	0.0833
p.P903S	TCGA-EE-A20C	SKCM	TCGA	SPTARVGPS	DEG_SIAH_1	0.2778
p.P903L	TCGA-EE-A20C	SKCM	TCGA	SPTARVGPS	DEG_SIAH_1	0.2778
p.P906Q	TCGA-EE-A2GI	SKCM	TCGA	SPTARVGPS	DEG_SIAH_1	0.7035
p.R919S	SIDM02039	Colorectal Carcinoma	GDSC	SPTARVGPS	DEG_SIAH_1	0.1667
p.A902T	SIDM01721	Non-Cancerous	GDSC	SPTARVGPS	DEG_SIAH_1	0.25
p.A902T	SIDM00191	Kidney Carcinoma	GDSC	SPTARVGPS	DEG_SIAH_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SIAH_1	905:913	SPTARVGPS	SIAH1,SIAH2,SIAH3	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons