DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PNTTS
Uniprot ID:
O75151
Source protein:
Lysine-specific demethylase PHF2
Source gene:
PHF2
Class:
DEG_SPOP_SBC_1
Location:
961:965
E3 ligase:
SPOP
DEGRON score:
0.9965
ASA_SCORE:
102.14
COIL:
0.9612
CONS_SCORE:
0.2869
DSS_SCORE:
0.652
HELIX:
0.0204
FCONS_SCORE:
1.0249
RIG_SCORE:
0.5796
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PHF2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PNTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00592
Podocalyxin
DEG_SPOP_SBC_1
143:147
PNTTS
SPOP
0.8566
More...
O15062
Zinc finger and BTB domain-containing protein 5
DEG_SPOP_SBC_1
432:436
PNTTS
SPOP
0.9996
More...
O75151
Lysine-specific demethylase PHF2
DEG_SPOP_SBC_1
961:965
PNTTS
SPOP
0.9965
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1144:1148
PNTTS
SPOP
0.9567
More...
Q86UP3
Zinc finger homeobox protein 4
DEG_SPOP_SBC_1
3450:3454
PNTTS
SPOP
0.7986
More...
Q8TF74
WAS/WASL-interacting protein family member 2
DEG_SPOP_SBC_1
162:166
PNTTS
SPOP
0.9644
More...
Q9UPV9
Trafficking kinesin-binding protein 1
DEG_SPOP_SBC_1
356:360
PNTTS
SPOP
0.9623
More...
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
DEG_SPOP_SBC_1
2442:2446
PNTTS
SPOP
0.6504
More...
Q9Y6X4
Soluble lamin-associated protein of 75 kDa
DEG_SPOP_SBC_1
562:566
PNTTS
SPOP
0.5576
More...