DegronMD

Uniprot ID: Q8NDH2

Source protein: Leucine-rich repeat transmembrane protein CCDC168

Source gene: CCDC168

Class: DEG_SPOP_SBC_1

Location: 2442:2446

E3 ligase: SPOP

DEGRON score: 0.6504

ASA_SCORE: 55.96

COIL: 0.5906

CONS_SCORE: 0.4473

DSS_SCORE: 0.5395

HELIX: 0.0996

FCONS_SCORE: 0.8396

RIG_SCORE: 0.708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2443L	TCGA-A5-A0G1	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	0.7667
p.S2443L	DO233752	GACA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.7667
p.S2443L	DO42472	UCEC	ICGC	PNTTS	DEG_SPOP_SBC_1	0.7667
p.W2432C	TCGA-B5-A3FA	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	0.0556
p.W2432C	DO52402	UCEC	ICGC	PNTTS	DEG_SPOP_SBC_1	0.0556
p.G2440E	DO7148	CLLE	ICGC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.L2442I	DO228974	LICA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.7174

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	143:147	PNTTS	SPOP	0.8566	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	432:436	PNTTS	SPOP	0.9996	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	961:965	PNTTS	SPOP	0.9965	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1144:1148	PNTTS	SPOP	0.9567	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	3450:3454	PNTTS	SPOP	0.7986	More...
Q8TF74	WAS/WASL-interacting protein family member 2	DEG_SPOP_SBC_1	162:166	PNTTS	SPOP	0.9644	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SPOP_SBC_1	356:360	PNTTS	SPOP	0.9623	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	2442:2446	PNTTS	SPOP	0.6504	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	562:566	PNTTS	SPOP	0.5576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons