DegronMD - Q9Y6X4(FAM169A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S561F	TCGA-2W-A8YY	CESC	TCGA	PNTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.3056
p.D634Y	TCGA-CU-A0YR	BLCA	TCGA	VDSSS	DEG_SPOP_SBC_1	633:637	Mutation altering degron motif	0.6214
p.S552P	TCGA-WE-A8K6	SKCM	TCGA	PNTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.0556
p.D574Y	DO449	BLCA	ICGC	PNTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.1111
p.S558C	DO755	BLCA	ICGC	PNTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.2222
p.S559C	DO46394	OV	ICGC	PNTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.25
p.D570Y	SIDM00282	Colorectal Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.2222
p.D570Y	CW-2	large intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.2222
p.A629V	SIDM00217	Colorectal Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	633:637	Mutation rewiring degron network	0.2222
p.A629V	SNU-1040	large intestine	COSMIC	VDSSS	DEG_SPOP_SBC_1	633:637	Mutation rewiring degron network	0.2222
p.A569V	ACH-000999	Colon/Colorectal Cancer	CCLE	PNTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.25
p.A569V	SNU-1040	large intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons