DegronMD

Uniprot ID: Q9Y6X4

Source protein: Soluble lamin-associated protein of 75 kDa

Source gene: FAM169A

Class: DEG_SPOP_SBC_1

Location: 562:566

E3 ligase: SPOP

DEGRON score: 0.5576

ASA_SCORE: 92.96

COIL: 0.9382

CONS_SCORE: 0.3977

DSS_SCORE: 0.7961

HELIX: 0.0316

FCONS_SCORE: 0.9096

RIG_SCORE: 0.614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S561F	TCGA-2W-A8YY	CESC	TCGA	PNTTS	DEG_SPOP_SBC_1	0.3056
p.S552P	TCGA-WE-A8K6	SKCM	TCGA	PNTTS	DEG_SPOP_SBC_1	0.0556
p.D574Y	DO449	BLCA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.1111
p.S558C	DO755	BLCA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.2222
p.S559C	DO46394	OV	ICGC	PNTTS	DEG_SPOP_SBC_1	0.25
p.D570Y	SIDM00282	Colorectal Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	0.2222
p.D570Y	CW-2	large_intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.2222
p.A569V	ACH-000999	Colon/Colorectal Cancer	CCLE	PNTTS	DEG_SPOP_SBC_1	0.25
p.A569V	SNU-1040	large_intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	143:147	PNTTS	SPOP	0.8566	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	432:436	PNTTS	SPOP	0.9996	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	961:965	PNTTS	SPOP	0.9965	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1144:1148	PNTTS	SPOP	0.9567	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	3450:3454	PNTTS	SPOP	0.7986	More...
Q8TF74	WAS/WASL-interacting protein family member 2	DEG_SPOP_SBC_1	162:166	PNTTS	SPOP	0.9644	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SPOP_SBC_1	356:360	PNTTS	SPOP	0.9623	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	2442:2446	PNTTS	SPOP	0.6504	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	562:566	PNTTS	SPOP	0.5576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons