DegronMD

Uniprot ID: O15062

Source protein: Zinc finger and BTB domain-containing protein 5

Source gene: ZBTB5

Class: DEG_SPOP_SBC_1

Location: 432:436

E3 ligase: SPOP

DEGRON score: 0.9996

ASA_SCORE: 72.5

COIL: 0.8524

CONS_SCORE: 0.9155

DSS_SCORE: 0.6516

HELIX: 0.078

FCONS_SCORE: 1.4578

RIG_SCORE: 0.7238

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N433S	TCGA-06-5416	GBM	TCGA	PNTTS	DEG_SPOP_SBC_1	0.5958
p.N433S	DO10880	GBM	ICGC	PNTTS	DEG_SPOP_SBC_1	0.5958
p.C438R	TCGA-B8-5550	KIRC	TCGA	PNTTS	DEG_SPOP_SBC_1	0.2778
p.C438R	DO17420	KIRC	ICGC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.P432T	TCGA-ZF-A9R4	BLCA	TCGA	PNTTS	DEG_SPOP_SBC_1	0.7031
p.P432T	DO219061	BLCA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	143:147	PNTTS	SPOP	0.8566	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	432:436	PNTTS	SPOP	0.9996	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	961:965	PNTTS	SPOP	0.9965	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1144:1148	PNTTS	SPOP	0.9567	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	3450:3454	PNTTS	SPOP	0.7986	More...
Q8TF74	WAS/WASL-interacting protein family member 2	DEG_SPOP_SBC_1	162:166	PNTTS	SPOP	0.9644	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SPOP_SBC_1	356:360	PNTTS	SPOP	0.9623	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	2442:2446	PNTTS	SPOP	0.6504	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	562:566	PNTTS	SPOP	0.5576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons