DegronMD - Q8NDH2(CCDC168)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S2443L	TCGA-A5-A0G1	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	2442:2446	Mutation altering degron motif	0.7667
p.S2443L	DO233752	GACA	ICGC	PNTTS	DEG_SPOP_SBC_1	2442:2446	Mutation altering degron motif	0.7667
p.S2443L	DO42472	UCEC	ICGC	PNTTS	DEG_SPOP_SBC_1	2442:2446	Mutation altering degron motif	0.7667
p.Q1679H	TCGA-AP-A0LM	UCEC	TCGA	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.1944
p.Q1679H	DO43306	UCEC	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.1944
p.T361A	TCGA-AX-A2HJ	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1389
p.T361A	DO51111	PRAD	ICGC	PFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1389
p.T361A	DO42105	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1389
p.E1698K	TCGA-AZ-4315	COAD	TCGA	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.1111
p.E1698K	TCGA-F5-6814	READ	TCGA	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.1111
p.E1698K	DO8842	COAD	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.1111
p.E1698K	DO228142	PBCA	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.1111
p.E1698K	DO36556	READ	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.1111
p.W2432C	TCGA-B5-A3FA	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	2442:2446	Mutation rewiring degron network	0.0556
p.W2432C	DO52402	UCEC	ICGC	PNTTS	DEG_SPOP_SBC_1	2442:2446	Mutation rewiring degron network	0.0556
p.S355P	TCGA-BS-A0UJ	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.3056
p.S355P	DO42745	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.3056
p.Q1681R	TCGA-DI-A1BU	UCEC	TCGA	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.25
p.Q1681R	DO42023	UCEC	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.25
p.T1687N	TCGA-E6-A1LX	UCEC	TCGA	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation altering degron motif	0.7055
p.T1687N	DO41020	UCEC	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation altering degron motif	0.7055
p.A359T	TCGA-EI-6917	READ	TCGA	PFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1944
p.A359T	DO36881	READ	ICGC	PFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.1944
p.E496D	TCGA-EO-A22R	UCEC	TCGA	SKLSLNVPSL	DEG_COP1_1	485:494	Mutation rewiring degron network	0.2778
p.E496D	DO42713	UCEC	ICGC	SKLSLNVPSL	DEG_COP1_1	485:494	Mutation rewiring degron network	0.2778
p.T340P	TCGA-EO-A3B0	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.T340P	DO219773	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.L2088I	TCGA-F5-6814	READ	TCGA	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation rewiring degron network	0.2222
p.L2088I	DO36556	READ	ICGC	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation rewiring degron network	0.2222
p.G2440E	DO7148	CLLE	ICGC	PNTTS	DEG_SPOP_SBC_1	2442:2446	Mutation rewiring degron network	0.2778
p.A1683T	DO228935	COCA	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.3056
p.S478F	DO222762	COCA	ICGC	SKLSLNVPSL	DEG_COP1_1	485:494	Mutation rewiring degron network	0.1389
p.S1696I	DO222884	COCA	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.1667
p.P1689L	DO223124	ESCA	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation altering degron motif	0.7582
p.L2442I	DO228974	LICA	ICGC	PNTTS	DEG_SPOP_SBC_1	2442:2446	Mutation altering degron motif	0.7174
p.Q2086E	DO25320	LUAD	ICGC	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation blocking phosphorylation signal	0.6111
p.P1691L	DO231075	LUSC	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.3056
p.S481L	DO222363	MELA	ICGC	SKLSLNVPSL	DEG_COP1_1	485:494	Mutation rewiring degron network	0.2222
p.S2089L	DO232842	NACA	ICGC	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation rewiring degron network	0.25
p.R2093H	SIDM02015	Colorectal Carcinoma	GDSC	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation altering degron motif	0.7133
p.E3139A	SIDM00068	Colorectal Carcinoma	GDSC	RKENV	DEG_APCC_KENBOX_2	3137:3141	Mutation altering degron motif	0.7701
p.S2108F	SIDM00068	Colorectal Carcinoma	GDSC	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation blocking phosphorylation signal	0.5278
p.A484T	ACH-000030	Lung Cancer	CCLE	SKLSLNVPSL	DEG_COP1_1	485:494	Mutation rewiring degron network	0.3056
p.A484T	ACH-000779	Lung Cancer	CCLE	SKLSLNVPSL	DEG_COP1_1	485:494	Mutation rewiring degron network	0.3056
p.H2104Y	ACH-000679	Esophageal Cancer	CCLE	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation substituting flanking lysine	0.3056
p.K479N	ACH-001401	Adrenal Cancer	CCLE	SKLSLNVPSL	DEG_COP1_1	485:494	Mutation substituting flanking lysine	0.2778
p.Q2108K	ACH-001853	Bile Duct Cancer	CCLE	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation blocking phosphorylation signal	0.5278
p.R486I	ACH-002046	Endometrial/Uterine Cancer	CCLE	SKLSLNVPSL	DEG_COP1_1	485:494	Mutation altering degron motif	0.8102

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC168

UniProt ID: Q8NDH2

Entrez ID:

Protein name: Leucine-rich repeat transmembrane protein CCDC168 (Coiled-coil domain-containing protein 168)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC168 in