DegronMD - Q8NDH2(CCDC168)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R486I	ACH-002046	Endometrial/Uterine Cancer	CCLE	SKLSLNVPSL	DEG_COP1_1	485:494	Mutation altering degron motif	0.8102
p.E3139A	SIDM00068	Colorectal Carcinoma	GDSC	RKENV	DEG_APCC_KENBOX_2	3137:3141	Mutation altering degron motif	0.7701
p.S2443L	TCGA-A5-A0G1	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	2442:2446	Mutation altering degron motif	0.7667
p.S2443L	DO233752	GACA	ICGC	PNTTS	DEG_SPOP_SBC_1	2442:2446	Mutation altering degron motif	0.7667
p.S2443L	DO42472	UCEC	ICGC	PNTTS	DEG_SPOP_SBC_1	2442:2446	Mutation altering degron motif	0.7667
p.P1689L	DO223124	ESCA	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation altering degron motif	0.7582
p.L2442I	DO228974	LICA	ICGC	PNTTS	DEG_SPOP_SBC_1	2442:2446	Mutation altering degron motif	0.7174
p.R2093H	SIDM02015	Colorectal Carcinoma	GDSC	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation altering degron motif	0.7133
p.T1687N	TCGA-E6-A1LX	UCEC	TCGA	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation altering degron motif	0.7055
p.T1687N	DO41020	UCEC	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation altering degron motif	0.7055
p.Q2086E	DO25320	LUAD	ICGC	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation blocking phosphorylation signal	0.6111
p.S2108F	SIDM00068	Colorectal Carcinoma	GDSC	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation blocking phosphorylation signal	0.5278
p.Q2108K	ACH-001853	Bile Duct Cancer	CCLE	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation blocking phosphorylation signal	0.5278
p.S355P	TCGA-BS-A0UJ	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.3056
p.S355P	DO42745	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.3056
p.A1683T	DO228935	COCA	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.3056
p.P1691L	DO231075	LUSC	ICGC	LSTPKTT	DEG_SCF_FBW7_1	1684:1690	Mutation rewiring degron network	0.3056
p.A484T	ACH-000030	Lung Cancer	CCLE	SKLSLNVPSL	DEG_COP1_1	485:494	Mutation rewiring degron network	0.3056
p.A484T	ACH-000779	Lung Cancer	CCLE	SKLSLNVPSL	DEG_COP1_1	485:494	Mutation rewiring degron network	0.3056
p.H2104Y	ACH-000679	Esophageal Cancer	CCLE	PRDTPWDE	DEG_SCF_FBW7_2	2092:2099	Mutation substituting flanking lysine	0.3056

Showing 1 to 20 of 48 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC168

UniProt ID: Q8NDH2

Entrez ID:

Protein name: Leucine-rich repeat transmembrane protein CCDC168 (Coiled-coil domain-containing protein 168)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC168 in