DegronMD

Uniprot ID: Q8NDH2

Source protein: Leucine-rich repeat transmembrane protein CCDC168

Source gene: CCDC168

Class: DEG_SCF_FBW7_1

Location: 1684:1690

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 83.8857

COIL: 0.8347

CONS_SCORE: 0.5016

DSS_SCORE: 0.4651

HELIX: 0.0477

FCONS_SCORE: 1.3184

RIG_SCORE: 0.747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1679H	TCGA-AP-A0LM	UCEC	TCGA	LSTPKTT	DEG_SCF_FBW7_1	0.1944
p.Q1679H	DO43306	UCEC	ICGC	LSTPKTT	DEG_SCF_FBW7_1	0.1944
p.E1698K	TCGA-AZ-4315	COAD	TCGA	LSTPKTT	DEG_SCF_FBW7_1	0.1111
p.E1698K	TCGA-F5-6814	READ	TCGA	LSTPKTT	DEG_SCF_FBW7_1	0.1111
p.E1698K	DO8842	COAD	ICGC	LSTPKTT	DEG_SCF_FBW7_1	0.1111
p.E1698K	DO228142	PBCA	ICGC	LSTPKTT	DEG_SCF_FBW7_1	0.1111
p.E1698K	DO36556	READ	ICGC	LSTPKTT	DEG_SCF_FBW7_1	0.1111
p.Q1681R	TCGA-DI-A1BU	UCEC	TCGA	LSTPKTT	DEG_SCF_FBW7_1	0.25
p.Q1681R	DO42023	UCEC	ICGC	LSTPKTT	DEG_SCF_FBW7_1	0.25
p.T1687N	TCGA-E6-A1LX	UCEC	TCGA	LSTPKTT	DEG_SCF_FBW7_1	0.7055
p.T1687N	DO41020	UCEC	ICGC	LSTPKTT	DEG_SCF_FBW7_1	0.7055
p.A1683T	DO228935	COCA	ICGC	LSTPKTT	DEG_SCF_FBW7_1	0.3056
p.S1696I	DO222884	COCA	ICGC	LSTPKTT	DEG_SCF_FBW7_1	0.1667
p.P1689L	DO223124	ESCA	ICGC	LSTPKTT	DEG_SCF_FBW7_1	0.7582
p.P1691L	DO231075	LUSC	ICGC	LSTPKTT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SCF_FBW7_1	1684:1690	LSTPKTT	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons