DegronMD

Uniprot ID: Q8NDH2

Source protein: Leucine-rich repeat transmembrane protein CCDC168

Source gene: CCDC168

Class: DEG_APCC_KENBOX_2

Location: 3137:3141

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7623

ASA_SCORE: 113.72

COIL: 0.6614

CONS_SCORE: 0

DSS_SCORE: 0.3698

HELIX: 0.1452

FCONS_SCORE: 0

RIG_SCORE: 0.7729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E3139A	SIDM00068	Colorectal Carcinoma	GDSC	RKENV	DEG_APCC_KENBOX_2	0.7701

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95727	Cytotoxic and regulatory T-cell molecule	DEG_APCC_KENBOX_2	372:376	RKENV	APC,CDC20,FZR1	0.8244	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_APCC_KENBOX_2	3137:3141	RKENV	APC,CDC20,FZR1	0.7623	More...
Q6ZU69	Protein FAM205A	DEG_APCC_KENBOX_2	1246:1250	RKENV	APC,CDC20,FZR1	0.7358	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons