DegronMD - Q6ZU69(FAM205A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1238V	TCGA-A5-A1OF	UCEC	TCGA	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.1111
p.A1238V	DO42568	UCEC	ICGC	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.1111
p.A1240V	TCGA-AZ-4315	COAD	TCGA	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.1667
p.A1240V	TCGA-EO-A3AU	UCEC	TCGA	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.1667
p.A1240V	DO8842	COAD	ICGC	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.1667
p.A1240V	DO43827	UCEC	ICGC	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.1667
p.F1236L	TCGA-AZ-4315	COAD	TCGA	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.0556
p.F1236L	DO8842	COAD	ICGC	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.0556
p.R351K	TCGA-B5-A1MR	UCEC	TCGA	LKNTPQVS	DEG_SCF_FBW7_1	341:348	Mutation rewiring degron network	0.25
p.R351K	DO41758	UCEC	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	341:348	Mutation rewiring degron network	0.25
p.S338Y	TCGA-BS-A0UF	UCEC	TCGA	LKNTPQVS	DEG_SCF_FBW7_1	341:348	Mutation rewiring degron network	0.25
p.S338Y	DO41488	UCEC	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	341:348	Mutation rewiring degron network	0.25
p.R1098Q	TCGA-D1-A16X	UCEC	TCGA	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.2778
p.R1098Q	DO41799	UCEC	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.2778
p.R351I	TCGA-DF-A2KN	UCEC	TCGA	LKNTPQVS	DEG_SCF_FBW7_1	341:348	Mutation rewiring degron network	0.25
p.R351I	DO223282	UCEC	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	341:348	Mutation rewiring degron network	0.25
p.W1099C	TCGA-DX-A48N	SARC	TCGA	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.25
p.W1099C	DO219986	SARC	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.25
p.R1101C	TCGA-FI-A2D0	UCEC	TCGA	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.1944
p.R1101C	DO43891	UCEC	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.1944
p.T1245A	TCGA-FI-A2D5	UCEC	TCGA	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.3056
p.T1245A	DO41331	UCEC	ICGC	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.3056
p.P1093S	TCGA-FI-A2D5	UCEC	TCGA	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation altering degron motif	0.6752
p.P1093S	DO41331	UCEC	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation altering degron motif	0.6752
p.R1101H	DO229013	COCA	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.1944
p.R1101H	DO229003	COCA	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.1944
p.R1101H	DO229005	COCA	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.1944
p.R1101H	DO230998	LUSC	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.1944
p.S1102R	DO50450	ESAD	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.1667
p.A1239T	DO233106	GACA	ICGC	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.1389
p.A1239T	SIDM00496	Thyroid Gland Carcinoma	GDSC	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.1389
p.A1239T	ACH-001350	Thyroid Cancer	CCLE	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.1389
p.A1239T	HTC-C3	thyroid	COSMIC	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.1389
p.L619I	DO233935	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.1111
p.P345S	DO231108	LAML	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	341:348	Mutation altering degron motif	0.6752
p.P345S	DO229095	THCA	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	341:348	Mutation altering degron motif	0.6752
p.R1083S	DO228941	LICA	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.1667
p.T566K	DO228948	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	562:566	Mutation altering degron motif	0.7306
p.A1079V	DO228955	LICA	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation rewiring degron network	0.0556
p.H159Q	DO229008	LICA	ICGC	VTPTLS	DEG_SCF_FBW7_1	168:173	Mutation rewiring degron network	0.0833
p.F352S	DO230525	LUSC	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	341:348	Mutation rewiring degron network	0.2222
p.F352S	DO230550	LUSC	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	341:348	Mutation rewiring degron network	0.2222
p.F352S	DO218888	SKCA	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	341:348	Mutation rewiring degron network	0.2222
p.L163F	DO222632	MELA	ICGC	VTPTLS	DEG_SCF_FBW7_1	168:173	Mutation rewiring degron network	0.1944
p.K1244N	DO35126	PACA	ICGC	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.2778
p.P1093T	SIDM00948	Burkitt's Lymphoma	GDSC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation altering degron motif	0.7031
p.S1096C	SIDM01084	Osteosarcoma	GDSC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation altering degron motif	0.7541
p.S1096C	ACH-000410	Bone Cancer	CCLE	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation altering degron motif	0.7541
p.S1096C	Saos-2	bone	COSMIC	PNKTPRGS	DEG_SCF_FBW7_1	1089:1096	Mutation altering degron motif	0.7541
p.A1243D	SIDM00996	Thyroid Gland Carcinoma	GDSC	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.25
p.A1243D	ACH-001307	Thyroid Cancer	CCLE	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.25
p.A1243D	8505C	thyroid	COSMIC	RKENV	DEG_APCC_KENBOX_2	1246:1250	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM205A

UniProt ID: Q6ZU69

Entrez ID: 259308

Protein name: Protein FAM205A

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FAM205A in