DegronMD

Uniprot ID: Q6ZU69

Source protein: Protein FAM205A

Source gene: FAM205A

Class: DEG_SCF_FBW7_1

Location: 1089:1096

E3 ligase: FBXW7

DEGRON score: 0.648

ASA_SCORE: 91.9

COIL: 0.9235

CONS_SCORE: 0.5867

DSS_SCORE: 0.5941

HELIX: 0.025

FCONS_SCORE: 1.0276

RIG_SCORE: 0.6183

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1098Q	TCGA-D1-A16X	UCEC	TCGA	PNKTPRGS	DEG_SCF_FBW7_1	0.2778
p.R1098Q	DO41799	UCEC	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	0.2778
p.W1099C	TCGA-DX-A48N	SARC	TCGA	PNKTPRGS	DEG_SCF_FBW7_1	0.25
p.W1099C	DO219986	SARC	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	0.25
p.R1101C	TCGA-FI-A2D0	UCEC	TCGA	PNKTPRGS	DEG_SCF_FBW7_1	0.1944
p.R1101C	DO43891	UCEC	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	0.1944
p.P1093S	TCGA-FI-A2D5	UCEC	TCGA	PNKTPRGS	DEG_SCF_FBW7_1	0.6752
p.P1093S	DO41331	UCEC	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	0.6752
p.R1101H	DO229013	COCA	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	0.1944
p.R1101H	DO229003	COCA	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	0.1944
p.R1101H	DO229005	COCA	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	0.1944
p.R1101H	DO230998	LUSC	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	0.1944
p.S1102R	DO50450	ESAD	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	0.1667
p.R1083S	DO228941	LICA	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	0.1667
p.A1079V	DO228955	LICA	ICGC	PNKTPRGS	DEG_SCF_FBW7_1	0.0556
p.P1093T	SIDM00948	Burkitt's Lymphoma	GDSC	PNKTPRGS	DEG_SCF_FBW7_1	0.7031
p.S1096C	SIDM01084	Osteosarcoma	GDSC	PNKTPRGS	DEG_SCF_FBW7_1	0.7541
p.S1096C	ACH-000410	Bone Cancer	CCLE	PNKTPRGS	DEG_SCF_FBW7_1	0.7541
p.S1096C	Saos-2	bone	COSMIC	PNKTPRGS	DEG_SCF_FBW7_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZU69	Protein FAM205A	DEG_SCF_FBW7_1	1089:1096	PNKTPRGS	FBXW7	0.648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons