DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VTPTLS
Uniprot ID:
Q6ZU69
Source protein:
Protein FAM205A
Source gene:
FAM205A
Class:
DEG_SCF_FBW7_1
Location:
168:173
E3 ligase:
FBXW7
DEGRON score:
0.9955
ASA_SCORE:
79.6167
COIL:
0.874
CONS_SCORE:
0.5381
DSS_SCORE:
0.3668
HELIX:
0.0858
FCONS_SCORE:
1.1543
RIG_SCORE:
0.7334
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H159Q
DO229008
LICA
ICGC
VTPTLS
DEG_SCF_FBW7_1
0.0833
p.L163F
DO222632
MELA
ICGC
VTPTLS
DEG_SCF_FBW7_1
0.1944
Drug responses associated with FAM205A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTPTLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IWV1
Lymphocyte transmembrane adapter 1
DEG_SCF_FBW7_1
4:9
VTPTLS
FBXW7
0.5009
More...
A6NFA0
Protein FAM205C
DEG_SCF_FBW7_1
168:173
VTPTLS
FBXW7
0.8082
More...
Q6ZU69
Protein FAM205A
DEG_SCF_FBW7_1
168:173
VTPTLS
FBXW7
0.9955
More...