DegronMD

Uniprot ID: Q8IWV1

Source protein: Lymphocyte transmembrane adapter 1

Source gene: LAX1

Class: DEG_SCF_FBW7_1

Location: 4:9

E3 ligase: FBXW7

DEGRON score: 0.5009

ASA_SCORE: 83.4667

COIL: 0.8213

CONS_SCORE: 0.5919

DSS_SCORE: 0.7347

HELIX: 0.127

FCONS_SCORE: 1.0414

RIG_SCORE: 0.7462

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2N	TCGA-D1-A16R	UCEC	TCGA	VTPTLS	DEG_SCF_FBW7_1	0.2778
p.D2N	TCGA-EE-A2GD	SKCM	TCGA	VTPTLS	DEG_SCF_FBW7_1	0.2778
p.D2N	TCGA-W3-AA1Q	SKCM	TCGA	VTPTLS	DEG_SCF_FBW7_1	0.2778
p.D2N	DO37603	SKCM	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.2778
p.D2N	DO219487	SKCM	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.2778
p.D2N	DO41831	UCEC	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.2778
p.G13W	TCGA-EE-A183	SKCM	TCGA	VTPTLS	DEG_SCF_FBW7_1	0.2222
p.G13W	DO37715	SKCM	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.2222
p.T7N	DO233101	GACA	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.5944
p.A11T	DO232027	LICA	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.2778
p.G3V	DO229022	LICA	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.3056
p.S18F	DO23336	LINC	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.0833
p.G13E	DO222662	MELA	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.2222
p.S3L	DO222702	MELA	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.3056
p.S3L	DO43202	UCEC	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.3056
p.S3L	DO42713	UCEC	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.3056
p.A9V	DO42105	UCEC	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.6936
p.A9V	DO223282	UCEC	ICGC	VTPTLS	DEG_SCF_FBW7_1	0.6936
p.F5L	COLO-792	skin	COSMIC	VTPTLS	DEG_SCF_FBW7_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWV1	Lymphocyte transmembrane adapter 1	DEG_SCF_FBW7_1	4:9	VTPTLS	FBXW7	0.5009	More...
A6NFA0	Protein FAM205C	DEG_SCF_FBW7_1	168:173	VTPTLS	FBXW7	0.8082	More...
Q6ZU69	Protein FAM205A	DEG_SCF_FBW7_1	168:173	VTPTLS	FBXW7	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons