DegronMD - Q8IWV1(LAX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A183T	TCGA-17-Z014	LUAD	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation rewiring degron network	0.2222
p.A183T	TCGA-XK-AAIW	PRAD	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation rewiring degron network	0.2222
p.S208C	TCGA-34-5927	LUSC	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation rewiring degron network	0.0833
p.A199S	TCGA-38-4626	LUAD	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation altering degron motif	0.7588
p.Q263E	TCGA-55-7283	LUAD	TCGA	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.2222
p.G248A	TCGA-55-7995	LUAD	TCGA	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.1667
p.S265P	TCGA-94-A4VJ	LUSC	TCGA	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.1667
p.S190L	TCGA-AA-3984	COAD	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation altering degron motif	0.6556
p.E204D	TCGA-AX-A05Z	UCEC	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation rewiring degron network	0.1944
p.D251N	TCGA-BT-A20O	BLCA	TCGA	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.25
p.D2N	TCGA-D1-A16R	UCEC	TCGA	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.2778
p.D2N	TCGA-EE-A2GD	SKCM	TCGA	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.2778
p.D2N	TCGA-W3-AA1Q	SKCM	TCGA	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.2778
p.D2N	DO37603	SKCM	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.2778
p.D2N	DO219487	SKCM	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.2778
p.D2N	DO41831	UCEC	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.2778
p.G13W	TCGA-EE-A183	SKCM	TCGA	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.2222
p.G13W	DO37715	SKCM	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.2222
p.Q263H	TCGA-EO-A3AY	UCEC	TCGA	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.2222
p.P197H	TCGA-OR-A5KB	ACC	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation altering degron motif	0.7694
p.S187L	TCGA-ZF-AA58	BLCA	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation altering degron motif	0.7667
p.S197P	DO48368	BLCA	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation altering degron motif	0.6752
p.E265K	DO51933	BLCA	ICGC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.1667
p.E265K	DO37404	SKCM	ICGC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.1667
p.A262V	DO51970	CLLE	ICGC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.25
p.A262V	DO8490	COAD	ICGC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.25
p.T7N	DO233101	GACA	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation altering degron motif	0.5944
p.V202F	DO228362	LICA	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation rewiring degron network	0.25
p.A187S	DO228986	LICA	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation altering degron motif	0.7588
p.A11T	DO232027	LICA	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.2778
p.S205I	DO229029	LICA	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation rewiring degron network	0.1667
p.G3V	DO229022	LICA	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.3056
p.S18F	DO23336	LINC	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.0833
p.A183S	DO24447	LUAD	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation rewiring degron network	0.2222
p.D259Y	DO23744	LUAD	ICGC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation altering degron motif	0.7325
p.T206N	DO45390	LUAD	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation rewiring degron network	0.1389
p.L200V	DO45390	LUAD	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation rewiring degron network	0.3056
p.Q247E	DO23606	LUAD	ICGC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.1389
p.Q247E	DO52686	MALY	ICGC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.1389
p.S192C	DO27731	LUSC	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation altering degron motif	0.7541
p.S249P	DO50104	LUSC	ICGC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.1944
p.G13E	DO222662	MELA	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.2222
p.S3L	DO222702	MELA	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.3056
p.S3L	DO43202	UCEC	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.3056
p.S3L	DO42713	UCEC	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation rewiring degron network	0.3056
p.L209M	DO46334	OV	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation rewiring degron network	0.0556
p.P196H	DO38033	SKCM	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation altering degron motif	0.7694
p.E188D	DO40884	UCEC	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	187:199	Mutation altering degron motif	0.5647
p.A9V	DO42105	UCEC	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation altering degron motif	0.6936
p.A9V	DO223282	UCEC	ICGC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation altering degron motif	0.6936
p.Q247H	DO43202	UCEC	ICGC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.1389
p.Q263R	SIDM01045	Endometrial Carcinoma	GDSC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.2222
p.Q263R	ACH-000978	Endometrial/Uterine Cancer	CCLE	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.2222
p.Q263R	EN	endometrium	COSMIC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.2222
p.E250Q	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.2222
p.Q267R	Daudi	haematopoietic and lymphoid tissue	COSMIC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.1111
p.Q247R	EN	endometrium	COSMIC	SLSNGE	DEG_Kelch_Keap1_1	254:259	Mutation rewiring degron network	0.1389
p.F5L	COLO-792	skin	COSMIC	VTPTLS	DEG_SCF_FBW7_1	4:9	Mutation altering degron motif	0.6981

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LAX1

UniProt ID: Q8IWV1

Entrez ID: 54900

Protein name: Lymphocyte transmembrane adapter 1 (Linker for activation of X cells) (Membrane-associated adapter protein LAX)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LAX1 in