DegronMD

Uniprot ID: Q8IWV1

Source protein: Lymphocyte transmembrane adapter 1

Source gene: LAX1

Class: DEG_Kelch_Keap1_1

Location: 254:259

E3 ligase: KEAP1

DEGRON score: 0.9914

ASA_SCORE: 77.15

COIL: 0.7905

CONS_SCORE: 0.7059

DSS_SCORE: 0.6162

HELIX: 0.1425

FCONS_SCORE: 1.0319

RIG_SCORE: 0.5879

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q263E	TCGA-55-7283	LUAD	TCGA	SLSNGE	DEG_Kelch_Keap1_1	0.2222
p.G248A	TCGA-55-7995	LUAD	TCGA	SLSNGE	DEG_Kelch_Keap1_1	0.1667
p.S265P	TCGA-94-A4VJ	LUSC	TCGA	SLSNGE	DEG_Kelch_Keap1_1	0.1667
p.D251N	TCGA-BT-A20O	BLCA	TCGA	SLSNGE	DEG_Kelch_Keap1_1	0.25
p.Q263H	TCGA-EO-A3AY	UCEC	TCGA	SLSNGE	DEG_Kelch_Keap1_1	0.2222
p.E265K	DO51933	BLCA	ICGC	SLSNGE	DEG_Kelch_Keap1_1	0.1667
p.E265K	DO37404	SKCM	ICGC	SLSNGE	DEG_Kelch_Keap1_1	0.1667
p.A262V	DO51970	CLLE	ICGC	SLSNGE	DEG_Kelch_Keap1_1	0.25
p.A262V	DO8490	COAD	ICGC	SLSNGE	DEG_Kelch_Keap1_1	0.25
p.D259Y	DO23744	LUAD	ICGC	SLSNGE	DEG_Kelch_Keap1_1	0.7325
p.Q247E	DO23606	LUAD	ICGC	SLSNGE	DEG_Kelch_Keap1_1	0.1389
p.Q247E	DO52686	MALY	ICGC	SLSNGE	DEG_Kelch_Keap1_1	0.1389
p.S249P	DO50104	LUSC	ICGC	SLSNGE	DEG_Kelch_Keap1_1	0.1944
p.Q247H	DO43202	UCEC	ICGC	SLSNGE	DEG_Kelch_Keap1_1	0.1389
p.Q263R	SIDM01045	Endometrial Carcinoma	GDSC	SLSNGE	DEG_Kelch_Keap1_1	0.2222
p.Q263R	ACH-000978	Endometrial/Uterine Cancer	CCLE	SLSNGE	DEG_Kelch_Keap1_1	0.2222
p.Q263R	EN	endometrium	COSMIC	SLSNGE	DEG_Kelch_Keap1_1	0.2222
p.E250Q	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	SLSNGE	DEG_Kelch_Keap1_1	0.2222
p.Q267R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SLSNGE	DEG_Kelch_Keap1_1	0.1111
p.Q247R	EN	endometrium	COSMIC	SLSNGE	DEG_Kelch_Keap1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWV1	Lymphocyte transmembrane adapter 1	DEG_Kelch_Keap1_1	254:259	SLSNGE	KEAP1	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons