DegronMD

Uniprot ID: Q8IWV1

Source protein: Lymphocyte transmembrane adapter 1

Source gene: LAX1

Class: DEG_COP1_1

Location: 187:199

E3 ligase: COP1

DEGRON score: 0.9979

ASA_SCORE: 76.0615

COIL: 0.7617

CONS_SCORE: 0.8126

DSS_SCORE: 0.4089

HELIX: 0.1569

FCONS_SCORE: 1.309

RIG_SCORE: 0.7219

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A183T	TCGA-17-Z014	LUAD	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	0.2222
p.A183T	TCGA-XK-AAIW	PRAD	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	0.2222
p.S208C	TCGA-34-5927	LUSC	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	0.0833
p.A199S	TCGA-38-4626	LUAD	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	0.7588
p.S190L	TCGA-AA-3984	COAD	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	0.6556
p.E204D	TCGA-AX-A05Z	UCEC	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	0.1944
p.P197H	TCGA-OR-A5KB	ACC	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	0.7694
p.S187L	TCGA-ZF-AA58	BLCA	TCGA	SEDSHDYVNVPTA	DEG_COP1_1	0.7667
p.S197P	DO48368	BLCA	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	0.6752
p.V202F	DO228362	LICA	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	0.25
p.A187S	DO228986	LICA	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	0.7588
p.S205I	DO229029	LICA	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	0.1667
p.A183S	DO24447	LUAD	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	0.2222
p.T206N	DO45390	LUAD	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	0.1389
p.L200V	DO45390	LUAD	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	0.3056
p.S192C	DO27731	LUSC	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	0.7541
p.L209M	DO46334	OV	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	0.0556
p.P196H	DO38033	SKCM	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	0.7694
p.E188D	DO40884	UCEC	ICGC	SEDSHDYVNVPTA	DEG_COP1_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWV1	Lymphocyte transmembrane adapter 1	DEG_COP1_1	187:199	SEDSHDYVNVPTA	COP1	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons