DegronMD

Uniprot ID: Q6ZU69

Source protein: Protein FAM205A

Source gene: FAM205A

Class: DEG_SCF_FBW7_1

Location: 341:348

E3 ligase: FBXW7

DEGRON score: 0.9168

ASA_SCORE: 80.4875

COIL: 0.8251

CONS_SCORE: 0.523

DSS_SCORE: 0.305

HELIX: 0.1119

FCONS_SCORE: 0.8353

RIG_SCORE: 0.7649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R351K	TCGA-B5-A1MR	UCEC	TCGA	LKNTPQVS	DEG_SCF_FBW7_1	0.25
p.R351K	DO41758	UCEC	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	0.25
p.S338Y	TCGA-BS-A0UF	UCEC	TCGA	LKNTPQVS	DEG_SCF_FBW7_1	0.25
p.S338Y	DO41488	UCEC	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	0.25
p.R351I	TCGA-DF-A2KN	UCEC	TCGA	LKNTPQVS	DEG_SCF_FBW7_1	0.25
p.R351I	DO223282	UCEC	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	0.25
p.P345S	DO231108	LAML	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	0.6752
p.P345S	DO229095	THCA	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	0.6752
p.F352S	DO230525	LUSC	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	0.2222
p.F352S	DO230550	LUSC	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	0.2222
p.F352S	DO218888	SKCA	ICGC	LKNTPQVS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZU69	Protein FAM205A	DEG_SCF_FBW7_1	341:348	LKNTPQVS	FBXW7	0.9168	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons