DegronMD

Uniprot ID: Q6ZU69

Source protein: Protein FAM205A

Source gene: FAM205A

Class: DEG_APCC_KENBOX_2

Location: 1246:1250

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7358

ASA_SCORE: 109.38

COIL: 0.3732

CONS_SCORE: 0.4761

DSS_SCORE: 0.5262

HELIX: 0.6058

FCONS_SCORE: 1.1308

RIG_SCORE: 0.742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1238V	TCGA-A5-A1OF	UCEC	TCGA	RKENV	DEG_APCC_KENBOX_2	0.1111
p.A1238V	DO42568	UCEC	ICGC	RKENV	DEG_APCC_KENBOX_2	0.1111
p.A1240V	TCGA-AZ-4315	COAD	TCGA	RKENV	DEG_APCC_KENBOX_2	0.1667
p.A1240V	TCGA-EO-A3AU	UCEC	TCGA	RKENV	DEG_APCC_KENBOX_2	0.1667
p.A1240V	DO8842	COAD	ICGC	RKENV	DEG_APCC_KENBOX_2	0.1667
p.A1240V	DO43827	UCEC	ICGC	RKENV	DEG_APCC_KENBOX_2	0.1667
p.F1236L	TCGA-AZ-4315	COAD	TCGA	RKENV	DEG_APCC_KENBOX_2	0.0556
p.F1236L	DO8842	COAD	ICGC	RKENV	DEG_APCC_KENBOX_2	0.0556
p.T1245A	TCGA-FI-A2D5	UCEC	TCGA	RKENV	DEG_APCC_KENBOX_2	0.3056
p.T1245A	DO41331	UCEC	ICGC	RKENV	DEG_APCC_KENBOX_2	0.3056
p.A1239T	DO233106	GACA	ICGC	RKENV	DEG_APCC_KENBOX_2	0.1389
p.A1239T	SIDM00496	Thyroid Gland Carcinoma	GDSC	RKENV	DEG_APCC_KENBOX_2	0.1389
p.A1239T	ACH-001350	Thyroid Cancer	CCLE	RKENV	DEG_APCC_KENBOX_2	0.1389
p.A1239T	HTC-C3	thyroid	COSMIC	RKENV	DEG_APCC_KENBOX_2	0.1389
p.K1244N	DO35126	PACA	ICGC	RKENV	DEG_APCC_KENBOX_2	0.2778
p.A1243D	SIDM00996	Thyroid Gland Carcinoma	GDSC	RKENV	DEG_APCC_KENBOX_2	0.25
p.A1243D	ACH-001307	Thyroid Cancer	CCLE	RKENV	DEG_APCC_KENBOX_2	0.25
p.A1243D	8505C	thyroid	COSMIC	RKENV	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95727	Cytotoxic and regulatory T-cell molecule	DEG_APCC_KENBOX_2	372:376	RKENV	APC,CDC20,FZR1	0.8244	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_APCC_KENBOX_2	3137:3141	RKENV	APC,CDC20,FZR1	0.7623	More...
Q6ZU69	Protein FAM205A	DEG_APCC_KENBOX_2	1246:1250	RKENV	APC,CDC20,FZR1	0.7358	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons