DegronMD

Uniprot ID: O95727

Source protein: Cytotoxic and regulatory T-cell molecule

Source gene: CRTAM

Class: DEG_APCC_KENBOX_2

Location: 372:376

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8244

ASA_SCORE: 125.1

COIL: 0.7498

CONS_SCORE: 0.2784

DSS_SCORE: 0.5369

HELIX: 0.1874

FCONS_SCORE: 0.7544

RIG_SCORE: 0.7116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H385R	TCGA-A5-A0G2	UCEC	TCGA	RKENV	DEG_APCC_KENBOX_2	0.0833
p.H385Y	TCGA-DD-AAEE	LIHC	TCGA	RKENV	DEG_APCC_KENBOX_2	0.0833
p.L381V	TCGA-EO-A22X	UCEC	TCGA	RKENV	DEG_APCC_KENBOX_2	0.1944
p.K384N	TCGA-F5-6814	READ	TCGA	RKENV	DEG_APCC_KENBOX_2	0.2222
p.K384N	SIDM00216	Colorectal Carcinoma	GDSC	RKENV	DEG_APCC_KENBOX_2	0.2222
p.K384N	ACH-000989	Colon/Colorectal Cancer	CCLE	RKENV	DEG_APCC_KENBOX_2	0.2222
p.K384N	SNU-175	large_intestine	COSMIC	RKENV	DEG_APCC_KENBOX_2	0.2222
p.E383D	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	RKENV	DEG_APCC_KENBOX_2	0.1389
p.E383D	ACH-000785	Lung Cancer	CCLE	RKENV	DEG_APCC_KENBOX_2	0.1389
p.E383D	NCI-H2126	lung	COSMIC	RKENV	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95727	Cytotoxic and regulatory T-cell molecule	DEG_APCC_KENBOX_2	372:376	RKENV	APC,CDC20,FZR1	0.8244	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_APCC_KENBOX_2	3137:3141	RKENV	APC,CDC20,FZR1	0.7623	More...
Q6ZU69	Protein FAM205A	DEG_APCC_KENBOX_2	1246:1250	RKENV	APC,CDC20,FZR1	0.7358	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons