DegronMD

Uniprot ID: Q8NDH2

Source protein: Leucine-rich repeat transmembrane protein CCDC168

Source gene: CCDC168

Class: DEG_COP1_1

Location: 485:494

E3 ligase: COP1

DEGRON score: 0.9991

ASA_SCORE: 78.67

COIL: 0.8409

CONS_SCORE: 0.266

DSS_SCORE: 0.5617

HELIX: 0.0776

FCONS_SCORE: 0.7919

RIG_SCORE: 0.713

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E496D	TCGA-EO-A22R	UCEC	TCGA	SKLSLNVPSL	DEG_COP1_1	0.2778
p.E496D	DO42713	UCEC	ICGC	SKLSLNVPSL	DEG_COP1_1	0.2778
p.S478F	DO222762	COCA	ICGC	SKLSLNVPSL	DEG_COP1_1	0.1389
p.S481L	DO222363	MELA	ICGC	SKLSLNVPSL	DEG_COP1_1	0.2222
p.A484T	ACH-000030	Lung Cancer	CCLE	SKLSLNVPSL	DEG_COP1_1	0.3056
p.A484T	ACH-000779	Lung Cancer	CCLE	SKLSLNVPSL	DEG_COP1_1	0.3056
p.K479N	ACH-001401	Adrenal Cancer	CCLE	SKLSLNVPSL	DEG_COP1_1	0.2778
p.R486I	ACH-002046	Endometrial/Uterine Cancer	CCLE	SKLSLNVPSL	DEG_COP1_1	0.8102

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_COP1_1	485:494	SKLSLNVPSL	COP1	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons