DegronMD

Uniprot ID: Q8NDH2

Source protein: Leucine-rich repeat transmembrane protein CCDC168

Source gene: CCDC168

Class: DEG_SCF_FBW7_2

Location: 2092:2099

E3 ligase: FBXW7

DEGRON score: 0.7737

ASA_SCORE: 84.45

COIL: 0.8436

CONS_SCORE: 0.5019

DSS_SCORE: 0.6139

HELIX: 0.0385

FCONS_SCORE: 0.9973

RIG_SCORE: 0.7176

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2088I	TCGA-F5-6814	READ	TCGA	PRDTPWDE	DEG_SCF_FBW7_2	0.2222
p.L2088I	DO36556	READ	ICGC	PRDTPWDE	DEG_SCF_FBW7_2	0.2222
p.Q2086E	DO25320	LUAD	ICGC	PRDTPWDE	DEG_SCF_FBW7_2	0.6111
p.S2089L	DO232842	NACA	ICGC	PRDTPWDE	DEG_SCF_FBW7_2	0.25
p.R2093H	SIDM02015	Colorectal Carcinoma	GDSC	PRDTPWDE	DEG_SCF_FBW7_2	0.7133
p.S2108F	SIDM00068	Colorectal Carcinoma	GDSC	PRDTPWDE	DEG_SCF_FBW7_2	0.5278
p.H2104Y	ACH-000679	Esophageal Cancer	CCLE	PRDTPWDE	DEG_SCF_FBW7_2	0.3056
p.Q2108K	ACH-001853	Bile Duct Cancer	CCLE	PRDTPWDE	DEG_SCF_FBW7_2	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SCF_FBW7_2	2092:2099	PRDTPWDE	FBXW7	0.7737	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons