DegronMD

Uniprot ID: Q9UPV9

Source protein: Trafficking kinesin-binding protein 1

Source gene: TRAK1

Class: DEG_SCF_FBW7_1

Location: 442:448

E3 ligase: FBXW7

DEGRON score: 0.9455

ASA_SCORE: 72.8

COIL: 0.8596

CONS_SCORE: 0.4108

DSS_SCORE: 0.2954

HELIX: 0.0763

FCONS_SCORE: 1.2738

RIG_SCORE: 0.7051

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V458I	TCGA-17-Z031	LUAD	TCGA	VSTPRSS	DEG_SCF_FBW7_1	0.0556
p.V458I	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VSTPRSS	DEG_SCF_FBW7_1	0.0556
p.V458I	ACH-000937	Leukemia	CCLE	VSTPRSS	DEG_SCF_FBW7_1	0.0556
p.V458I	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	0.0556
p.D436N	DO8264	COAD	ICGC	VSTPRSS	DEG_SCF_FBW7_1	0.1667
p.A440V	DO233731	GACA	ICGC	VSTPRSS	DEG_SCF_FBW7_1	0.2778
p.A440V	DO38328	STAD	ICGC	VSTPRSS	DEG_SCF_FBW7_1	0.2778
p.R448L	DO228944	LICA	ICGC	VSTPRSS	DEG_SCF_FBW7_1	0.8428
p.R448Q	DO51511	PACA	ICGC	VSTPRSS	DEG_SCF_FBW7_1	0.7329
p.R448Q	DO219776	UCEC	ICGC	VSTPRSS	DEG_SCF_FBW7_1	0.7329
p.R443W	DO47889	STAD	ICGC	VSTPRSS	DEG_SCF_FBW7_1	0.8634
p.E454D	DO229275	THCA	ICGC	VSTPRSS	DEG_SCF_FBW7_1	0.1667
p.G451C	SIDM00014	Colorectal Carcinoma	GDSC	VSTPRSS	DEG_SCF_FBW7_1	0.25
p.G451C	LIM1215	large_intestine	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	0.25
p.V442F	SIDM00954	Breast Carcinoma	GDSC	VSTPRSS	DEG_SCF_FBW7_1	0.7068
p.V442F	COLO-824	breast	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	0.7068
p.I454M	SIDM00363	Acute Myeloid Leukemia	GDSC	VSTPRSS	DEG_SCF_FBW7_1	0.1667
p.I454M	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	0.1667
p.A454V	ACH-001021	Liver Cancer	CCLE	VSTPRSS	DEG_SCF_FBW7_1	0.1667
p.A454V	C3A	liver	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	0.1667
p.H446D	NCI-H226	lung	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	0.7688
p.R448C	SBC-5	lung	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SCF_FBW7_1	442:448	VSTPRSS	FBXW7	0.9455	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons