DegronMD

Uniprot ID: Q9UPV9

Source protein: Trafficking kinesin-binding protein 1

Source gene: TRAK1

Class: DEG_SCF_FBW7_1

Location: 538:543

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 58.3333

COIL: 0.7747

CONS_SCORE: 0.407

DSS_SCORE: 0.5103

HELIX: 0.1223

FCONS_SCORE: 1.2463

RIG_SCORE: 0.7009

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S535I	TCGA-67-3774	LUAD	TCGA	LTPTES	DEG_SCF_FBW7_1	0.25
p.R534H	TCGA-A5-A1OF	UCEC	TCGA	LTPTES	DEG_SCF_FBW7_1	0.2222
p.R552H	TCGA-CD-A4MJ	STAD	TCGA	LTPTES	DEG_SCF_FBW7_1	0.0833
p.R534C	TCGA-CM-5349	COAD	TCGA	LTPTES	DEG_SCF_FBW7_1	0.2222
p.S537F	TCGA-GN-A263	SKCM	TCGA	LTPTES	DEG_SCF_FBW7_1	0.3056
p.L547P	TCGA-GV-A3QF	BLCA	TCGA	LTPTES	DEG_SCF_FBW7_1	0.2222
p.E542K	TCGA-LN-A7HV	ESCA	TCGA	LTPTES	DEG_SCF_FBW7_1	0.591
p.E542K	SIDM02042	Pancreatic Carcinoma	GDSC	LTPTES	DEG_SCF_FBW7_1	0.591
p.S541T	DO227987	COCA	ICGC	LTPTES	DEG_SCF_FBW7_1	0.7116
p.W552R	DO234184	ESAD	ICGC	LTPTES	DEG_SCF_FBW7_1	0.0833
p.R545H	DO234292	ESAD	ICGC	LTPTES	DEG_SCF_FBW7_1	0.2778
p.D546Y	DO45431	LUSC	ICGC	LTPTES	DEG_SCF_FBW7_1	0.25
p.L536F	DO51298	SKCM	ICGC	LTPTES	DEG_SCF_FBW7_1	0.2778
p.R550H	DO52399	UCEC	ICGC	LTPTES	DEG_SCF_FBW7_1	0.1389
p.A533V	DO42512	UCEC	ICGC	LTPTES	DEG_SCF_FBW7_1	0.1944
p.C551R	DO41133	UCEC	ICGC	LTPTES	DEG_SCF_FBW7_1	0.1111
p.A528V	SIDM01237	Hepatocellular Carcinoma	GDSC	LTPTES	DEG_SCF_FBW7_1	0.0556
p.A528V	C3A	liver	COSMIC	LTPTES	DEG_SCF_FBW7_1	0.0556
p.P549L	SIDM00705	Non-Cancerous	GDSC	LTPTES	DEG_SCF_FBW7_1	0.1667
p.H550D	SIDM00139	Mesothelioma	GDSC	LTPTES	DEG_SCF_FBW7_1	0.1389
p.H550D	NCI-H226	lung	COSMIC	LTPTES	DEG_SCF_FBW7_1	0.1389
p.R552C	SIDM00368	Small Cell Lung Carcinoma	GDSC	LTPTES	DEG_SCF_FBW7_1	0.0833
p.R552C	SBC-5	lung	COSMIC	LTPTES	DEG_SCF_FBW7_1	0.0833
p.W552C	SIDM00996	Thyroid Gland Carcinoma	GDSC	LTPTES	DEG_SCF_FBW7_1	0.0833
p.W552C	SIDM00575	Glioma	GDSC	LTPTES	DEG_SCF_FBW7_1	0.0833
p.W552C	8505C	thyroid	COSMIC	LTPTES	DEG_SCF_FBW7_1	0.0833
p.W552C	NMC-G1	central_nervous_system	COSMIC	LTPTES	DEG_SCF_FBW7_1	0.0833
p.T549M	SIDM01608	Endometrial Carcinoma	GDSC	LTPTES	DEG_SCF_FBW7_1	0.1667
p.R537C	BFTC-905	urinary_tract	COSMIC	LTPTES	DEG_SCF_FBW7_1	0.3056
p.A539V	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	LTPTES	DEG_SCF_FBW7_1	0.6936
p.T529I	LS-411N	large_intestine	COSMIC	LTPTES	DEG_SCF_FBW7_1	0.0833
p.A535V	SNU-1040	large_intestine	COSMIC	LTPTES	DEG_SCF_FBW7_1	0.25
p.A551V	KGN	ovary	COSMIC	LTPTES	DEG_SCF_FBW7_1	0.1111
p.S534Y	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	LTPTES	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPTES

Degron related mutations and impact score

Drug responses associated with TRAK1 mutations

All proteins holding degron of LTPTES

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SCF_FBW7_1	538:543	LTPTES	FBXW7	0.9994	More...