DegronMD

Uniprot ID: Q9UPV9

Source protein: Trafficking kinesin-binding protein 1

Source gene: TRAK1

Class: DEG_SCF_FBW7_1

Location: 778:785

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 80.75

COIL: 0.9729

CONS_SCORE: 0.3635

DSS_SCORE: 0.6252

HELIX: 0.0085

FCONS_SCORE: 1.1615

RIG_SCORE: 0.5905

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S785L	TCGA-EE-A2GI	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	0.7667
p.S785L	DO37410	SKCM	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.7667
p.P782Q	TCGA-EE-A183	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	0.7035
p.P782Q	DO37715	SKCM	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.7035
p.P782S	TCGA-BF-A3DM	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	0.6752
p.P782S	DO222363	MELA	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.6752
p.P782S	DO48667	SKCM	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.6752
p.I778L	TCGA-B5-A11E	UCEC	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	0.6063
p.I778L	DO41644	UCEC	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.6063
p.P774L	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	IPSTPPNS	DEG_SCF_FBW7_1	0.3333
p.V777A	TCGA-A5-A1OF	UCEC	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	0.3056
p.V777A	DO42568	UCEC	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.3056
p.P776L	NCI-H1563	lung	COSMIC	IPSTPPNS	DEG_SCF_FBW7_1	0.2778
p.M775I	DO227880	COCA	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.25
p.M775V	SIDM00803	Kidney Carcinoma	GDSC	IPSTPPNS	DEG_SCF_FBW7_1	0.25
p.M775V	ACH-000411	Kidney Cancer	CCLE	IPSTPPNS	DEG_SCF_FBW7_1	0.25
p.M775V	769-P	kidney	COSMIC	IPSTPPNS	DEG_SCF_FBW7_1	0.25
p.T772M	DO228946	LICA	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.1667
p.T772M	DO230550	LUSC	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.1667
p.Y771C	SIDM00487	Colorectal Carcinoma	GDSC	IPSTPPNS	DEG_SCF_FBW7_1	0.1389
p.Y771C	ACH-000963	Colon/Colorectal Cancer	CCLE	IPSTPPNS	DEG_SCF_FBW7_1	0.1389
p.Y771C	CCK-81	large_intestine	COSMIC	IPSTPPNS	DEG_SCF_FBW7_1	0.1389
p.S770A	TCGA-AA-3663	COAD	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	0.1111
p.S770A	DO9346	COAD	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.1111
p.P795S	ACH-001970	Metastasis	CCLE	IPSTPPNS	DEG_SCF_FBW7_1	0.0556

Showing 1 to 25 of 25 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SCF_FBW7_1	778:785	IPSTPPNS	FBXW7	0.9989	More...
O60296	Trafficking kinesin-binding protein 2	DEG_SCF_FBW7_1	773:780	IPSTPPNS	FBXW7	0.9855	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons