DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IPSTPPNS
Uniprot ID:
Q9UPV9
Source protein:
Trafficking kinesin-binding protein 1
Source gene:
TRAK1
Class:
DEG_SCF_FBW7_1
Location:
778:785
E3 ligase:
FBXW7
DEGRON score:
0.9989
ASA_SCORE:
80.75
COIL:
0.9729
CONS_SCORE:
0.3635
DSS_SCORE:
0.6252
HELIX:
0.0085
FCONS_SCORE:
1.1615
RIG_SCORE:
0.5905
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V777A
TCGA-A5-A1OF
UCEC
TCGA
IPSTPPNS
DEG_SCF_FBW7_1
0.3056
p.V777A
DO42568
UCEC
ICGC
IPSTPPNS
DEG_SCF_FBW7_1
0.3056
p.S770A
TCGA-AA-3663
COAD
TCGA
IPSTPPNS
DEG_SCF_FBW7_1
0.1111
p.S770A
DO9346
COAD
ICGC
IPSTPPNS
DEG_SCF_FBW7_1
0.1111
p.I778L
TCGA-B5-A11E
UCEC
TCGA
IPSTPPNS
DEG_SCF_FBW7_1
0.6063
p.I778L
DO41644
UCEC
ICGC
IPSTPPNS
DEG_SCF_FBW7_1
0.6063
p.P782S
TCGA-BF-A3DM
SKCM
TCGA
IPSTPPNS
DEG_SCF_FBW7_1
0.6752
p.P782S
DO222363
MELA
ICGC
IPSTPPNS
DEG_SCF_FBW7_1
0.6752
p.P782S
DO48667
SKCM
ICGC
IPSTPPNS
DEG_SCF_FBW7_1
0.6752
p.P782Q
TCGA-EE-A183
SKCM
TCGA
IPSTPPNS
DEG_SCF_FBW7_1
0.7035
p.P782Q
DO37715
SKCM
ICGC
IPSTPPNS
DEG_SCF_FBW7_1
0.7035
p.S785L
TCGA-EE-A2GI
SKCM
TCGA
IPSTPPNS
DEG_SCF_FBW7_1
0.7667
p.S785L
DO37410
SKCM
ICGC
IPSTPPNS
DEG_SCF_FBW7_1
0.7667
p.M775I
DO227880
COCA
ICGC
IPSTPPNS
DEG_SCF_FBW7_1
0.25
p.T772M
DO228946
LICA
ICGC
IPSTPPNS
DEG_SCF_FBW7_1
0.1667
p.T772M
DO230550
LUSC
ICGC
IPSTPPNS
DEG_SCF_FBW7_1
0.1667
p.M775V
SIDM00803
Kidney Carcinoma
GDSC
IPSTPPNS
DEG_SCF_FBW7_1
0.25
p.M775V
ACH-000411
Kidney Cancer
CCLE
IPSTPPNS
DEG_SCF_FBW7_1
0.25
p.M775V
769-P
kidney
COSMIC
IPSTPPNS
DEG_SCF_FBW7_1
0.25
p.Y771C
SIDM00487
Colorectal Carcinoma
GDSC
IPSTPPNS
DEG_SCF_FBW7_1
0.1389
p.Y771C
ACH-000963
Colon/Colorectal Cancer
CCLE
IPSTPPNS
DEG_SCF_FBW7_1
0.1389
p.Y771C
CCK-81
large_intestine
COSMIC
IPSTPPNS
DEG_SCF_FBW7_1
0.1389
p.P795S
ACH-001970
Metastasis
CCLE
IPSTPPNS
DEG_SCF_FBW7_1
0.0556
p.P774L
IM-9
haematopoietic_and_lymphoid_tissue
COSMIC
IPSTPPNS
DEG_SCF_FBW7_1
0.3333
p.P776L
NCI-H1563
lung
COSMIC
IPSTPPNS
DEG_SCF_FBW7_1
0.2778
Drug responses associated with TRAK1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IPSTPPNS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60296
Trafficking kinesin-binding protein 2
DEG_SCF_FBW7_1
773:780
IPSTPPNS
FBXW7
0.9855
More...
Q9UPV9
Trafficking kinesin-binding protein 1
DEG_SCF_FBW7_1
778:785
IPSTPPNS
FBXW7
0.9989
More...