DegronMD

Uniprot ID: O60296

Source protein: Trafficking kinesin-binding protein 2

Source gene: TRAK2

Class: DEG_SCF_FBW7_1

Location: 773:780

E3 ligase: FBXW7

DEGRON score: 0.9855

ASA_SCORE: 92.8875

COIL: 0.9791

CONS_SCORE: 0.5173

DSS_SCORE: 0.6387

HELIX: 0.0066

FCONS_SCORE: 1.2555

RIG_SCORE: 0.5044

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P778L	TCGA-13-1494	OV	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	0.6471
p.P778L	DO32698	OV	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.6471
p.A772S	TCGA-55-8514	LUAD	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	0.3056
p.A772S	DO23616	LUAD	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.3056
p.P763L	TCGA-FS-A4FB	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	0.0556
p.P763L	DO37790	SKCM	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.0556
p.P768S	TCGA-FW-A3R5	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	0.1944
p.P768S	DO37406	SKCM	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.1944
p.S770F	DO220877	MELA	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.25
p.P785S	DO46438	OV	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	0.1944
p.K769Q	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	IPSTPPNS	DEG_SCF_FBW7_1	0.3333
p.K769Q	ACH-000853	Lung Cancer	CCLE	IPSTPPNS	DEG_SCF_FBW7_1	0.3333
p.K769Q	NCI-H661	lung	COSMIC	IPSTPPNS	DEG_SCF_FBW7_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60296	Trafficking kinesin-binding protein 2	DEG_SCF_FBW7_1	773:780	IPSTPPNS	FBXW7	0.9855	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SCF_FBW7_1	778:785	IPSTPPNS	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons