DegronMD - O60296(TRAK2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P778L	TCGA-13-1494	OV	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation altering degron motif	0.6471
p.P778L	DO32698	OV	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation altering degron motif	0.6471
p.V521F	TCGA-53-7624	LUAD	TCGA	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation rewiring degron network	0.2222
p.V521F	DO25058	LUAD	ICGC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation rewiring degron network	0.2222
p.A772S	TCGA-55-8514	LUAD	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation rewiring degron network	0.3056
p.A772S	DO23616	LUAD	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation rewiring degron network	0.3056
p.P527L	TCGA-86-7714	LUAD	TCGA	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation altering degron motif	0.7582
p.P527L	DO24870	LUAD	ICGC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation altering degron motif	0.7582
p.P906L	TCGA-A5-A1OK	UCEC	TCGA	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.3056
p.P906L	DO42376	UCEC	ICGC	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.3056
p.P900T	TCGA-EE-A2GI	SKCM	TCGA	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.3056
p.P900T	DO37410	SKCM	ICGC	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.3056
p.M894I	TCGA-EE-A2M8	SKCM	TCGA	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.1389
p.M894I	DO38075	SKCM	ICGC	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.1389
p.A899V	TCGA-EP-A26S	LIHC	TCGA	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.2778
p.A899V	DO22854	LIHC	ICGC	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.2778
p.A899P	TCGA-EP-A26S	LIHC	TCGA	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.2778
p.A899P	DO22854	LIHC	ICGC	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.2778
p.P763L	TCGA-FS-A4FB	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation rewiring degron network	0.0556
p.P763L	DO37790	SKCM	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation rewiring degron network	0.0556
p.P768S	TCGA-FW-A3R5	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation rewiring degron network	0.1944
p.P768S	DO37406	SKCM	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation rewiring degron network	0.1944
p.T528I	DO229010	COCA	ICGC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation altering degron motif	0.5966
p.T528I	DO229013	COCA	ICGC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation altering degron motif	0.5966
p.T528I	DO234285	ESAD	ICGC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation altering degron motif	0.5966
p.T528I	DO229346	LAML	ICGC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation altering degron motif	0.5966
p.T528I	DO228947	LICA	ICGC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation altering degron motif	0.5966
p.T528I	DO231007	LUSC	ICGC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation altering degron motif	0.5966
p.C535Y	DO233797	GACA	ICGC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation rewiring degron network	0.1944
p.P527Q	DO228976	LICA	ICGC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation altering degron motif	0.7035
p.S770F	DO220877	MELA	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation rewiring degron network	0.25
p.P785S	DO46438	OV	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation rewiring degron network	0.1944
p.K912R	SIDM00392	Melanoma	GDSC	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation substituting flanking lysine	0.25
p.K912R	ACH-000810	Skin Cancer	CCLE	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation substituting flanking lysine	0.25
p.K912R	SK-MEL-30	skin	COSMIC	VCTSS	DEG_SPOP_SBC_1	901:905	Mutation substituting flanking lysine	0.25
p.K769Q	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation substituting flanking lysine	0.3333
p.K769Q	ACH-000853	Lung Cancer	CCLE	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation substituting flanking lysine	0.3333
p.K769Q	NCI-H661	lung	COSMIC	IPSTPPNS	DEG_SCF_FBW7_1	773:780	Mutation substituting flanking lysine	0.3333
p.L531I	SIDM00151	Ovarian Carcinoma	GDSC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation rewiring degron network	0.3056
p.L531I	ACH-000966	Ovarian Cancer	CCLE	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation rewiring degron network	0.3056
p.L531I	IGROV-1	ovary	COSMIC	VTPTES	DEG_SCF_FBW7_1	525:530	Mutation rewiring degron network	0.3056

Kaplan plot for TRAK2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRAK2

UniProt ID: O60296

Entrez ID: 66008

Protein name: Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TRAK2 in