DegronMD

Uniprot ID: O60296

Source protein: Trafficking kinesin-binding protein 2

Source gene: TRAK2

Class: DEG_SPOP_SBC_1

Location: 901:905

E3 ligase: SPOP

DEGRON score: 0.7725

ASA_SCORE: 83.16

COIL: 0.8714

CONS_SCORE: 0.3462

DSS_SCORE: 0.2956

HELIX: 0.0204

FCONS_SCORE: 0.9391

RIG_SCORE: 0.7463

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P906L	TCGA-A5-A1OK	UCEC	TCGA	VCTSS	DEG_SPOP_SBC_1	0.3056
p.P906L	DO42376	UCEC	ICGC	VCTSS	DEG_SPOP_SBC_1	0.3056
p.P900T	TCGA-EE-A2GI	SKCM	TCGA	VCTSS	DEG_SPOP_SBC_1	0.3056
p.P900T	DO37410	SKCM	ICGC	VCTSS	DEG_SPOP_SBC_1	0.3056
p.M894I	TCGA-EE-A2M8	SKCM	TCGA	VCTSS	DEG_SPOP_SBC_1	0.1389
p.M894I	DO38075	SKCM	ICGC	VCTSS	DEG_SPOP_SBC_1	0.1389
p.A899V	TCGA-EP-A26S	LIHC	TCGA	VCTSS	DEG_SPOP_SBC_1	0.2778
p.A899V	DO22854	LIHC	ICGC	VCTSS	DEG_SPOP_SBC_1	0.2778
p.A899P	TCGA-EP-A26S	LIHC	TCGA	VCTSS	DEG_SPOP_SBC_1	0.2778
p.A899P	DO22854	LIHC	ICGC	VCTSS	DEG_SPOP_SBC_1	0.2778
p.K912R	SIDM00392	Melanoma	GDSC	VCTSS	DEG_SPOP_SBC_1	0.25
p.K912R	ACH-000810	Skin Cancer	CCLE	VCTSS	DEG_SPOP_SBC_1	0.25
p.K912R	SK-MEL-30	skin	COSMIC	VCTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60296	Trafficking kinesin-binding protein 2	DEG_SPOP_SBC_1	901:905	VCTSS	SPOP	0.7725	More...
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2935:2939	VCTSS	SPOP	0.988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons