DegronMD - O75592(MYCBP2)

FUNCTION: Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (By similarity). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity). Regulates axon guidance in the olfactory system (By similarity). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (By similarity). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (PubMed:29643511). Regulates the internalization of TRPV1 in peripheral sensory neurons (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (PubMed:18308511, PubMed:27278822). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (PubMed:9689053). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). {ECO:0000250|UniProtKB:Q7TPH6, ECO:0000269|PubMed:18308511, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26304119, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:29643511, ECO:0000269|PubMed:9689053}. View more >>

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K2845N	TCGA-23-1116	OV	TCGA	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation rewiring degron network	0.3056
p.V3214M	TCGA-2W-A8YY	CESC	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation substituting flanking lysine	0.2778
p.V3214M	DO223732	CESC	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation substituting flanking lysine	0.2778
p.S3236I	TCGA-43-2581	LUSC	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.0556
p.S3236I	DO26602	LUSC	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.0556
p.S3623L	TCGA-66-2778	LUSC	TCGA	SKENS	DEG_APCC_KENBOX_2	3619:3623	Mutation altering degron motif	0.6556
p.P2948L	TCGA-A5-A0G2	UCEC	TCGA	VCTSS	DEG_SPOP_SBC_1	2935:2939	Mutation rewiring degron network	0.0833
p.H3616Y	TCGA-A8-A095	BRCA	TCGA	SKENS	DEG_APCC_KENBOX_2	3619:3623	Mutation rewiring degron network	0.25
p.D3428G	TCGA-AA-3852	COAD	TCGA	ISVTPDAS	DEG_SCF_FBW7_1	3432:3439	Mutation rewiring degron network	0.2222
p.K2718N	TCGA-AC-A23H	BRCA	TCGA	PASTS	DEG_SPOP_SBC_1	2725:2729	Mutation rewiring degron network	0.1389
p.R2844C	TCGA-AD-A5EJ	COAD	TCGA	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation altering degron motif	0.8301
p.R2844C	TCGA-BR-4370	STAD	TCGA	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation altering degron motif	0.8301
p.H3797Y	TCGA-AG-3893	READ	TCGA	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation altering degron motif	0.7229
p.R3617C	TCGA-AG-A002	READ	TCGA	SKENS	DEG_APCC_KENBOX_2	3619:3623	Mutation rewiring degron network	0.2778
p.R2830C	TCGA-AJ-A3EK	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation rewiring degron network	0.0556
p.R2830C	ACH-001377	Pancreatic Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation rewiring degron network	0.0556
p.E2013K	TCGA-AN-A046	BRCA	TCGA	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation altering degron motif	0.7022
p.E2013K	TCGA-AX-A0J0	UCEC	TCGA	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation altering degron motif	0.7022
p.D2841Y	TCGA-AX-A1CE	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation altering degron motif	0.7325
p.Y3216D	TCGA-DD-AAD8	LIHC	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.2222
p.Y3216D	DO52226	LIHC	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.2222
p.R3227Q	TCGA-DF-A2KU	UCEC	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.3056
p.R3227Q	DO222919	BTCA	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.3056
p.R3227Q	DO223286	UCEC	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.3056
p.D2015N	TCGA-DF-A2KU	UCEC	TCGA	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation altering degron motif	0.6932
p.P3806S	TCGA-EE-A182	SKCM	TCGA	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation rewiring degron network	0.1667
p.P3223Q	TCGA-EE-A2GR	SKCM	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation altering degron motif	0.7035
p.P3223Q	DO37996	SKCM	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation altering degron motif	0.7035
p.R3437I	TCGA-EJ-5519	PRAD	TCGA	ISVTPDAS	DEG_SCF_FBW7_1	3432:3439	Mutation altering degron motif	0.8102
p.P2840L	TCGA-ER-A19S	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation altering degron motif	0.7582
p.A3229T	TCGA-HU-A4GT	STAD	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.25
p.A3229T	DO48020	STAD	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.25
p.E2724K	TCGA-R6-A8W8	ESCA	TCGA	PASTS	DEG_SPOP_SBC_1	2725:2729	Mutation rewiring degron network	0.3056
p.L2854F	TCGA-ZF-AA4X	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation rewiring degron network	0.0556
p.S3440L	TCGA-ZF-AA58	BLCA	TCGA	ISVTPDAS	DEG_SCF_FBW7_1	3432:3439	Mutation rewiring degron network	0.3056
p.E2008K	DO48439	BLCA	ICGC	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation rewiring degron network	0.1944
p.E2008K	SIDM00447	B-Lymphoblastic Leukemia	GDSC	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation rewiring degron network	0.1944
p.E2024Q	DO218999	BLCA	ICGC	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation rewiring degron network	0.1389
p.N3785K	DO223732	CESC	ICGC	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation rewiring degron network	0.0556
p.T2016A	DO10068	COAD	ICGC	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation altering degron motif	0.7139
p.N3785S	DO8264	COAD	ICGC	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation rewiring degron network	0.0556
p.N3616K	DO21235	LAML	ICGC	SKENS	DEG_APCC_KENBOX_2	3619:3623	Mutation rewiring degron network	0.25
p.N3616K	DO28281	OV	ICGC	SKENS	DEG_APCC_KENBOX_2	3619:3623	Mutation rewiring degron network	0.25
p.E3612D	DO22237	LGG	ICGC	SKENS	DEG_APCC_KENBOX_2	3619:3623	Mutation rewiring degron network	0.1389
p.T2003K	DO228948	LICA	ICGC	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation rewiring degron network	0.0556
p.T2003K	DO229015	LICA	ICGC	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation rewiring degron network	0.0556
p.Q3232K	DO228952	LICA	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.1667
p.H3217N	DO229015	LICA	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.25
p.T3618K	DO229031	LICA	ICGC	SKENS	DEG_APCC_KENBOX_2	3619:3623	Mutation rewiring degron network	0.3056
p.P3213T	DO229037	LICA	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation rewiring degron network	0.1389
p.H3798N	DO229009	LICA	ICGC	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation altering degron motif	0.7423
p.E3621K	DO219565	LIHC	ICGC	SKENS	DEG_APCC_KENBOX_2	3619:3623	Mutation altering degron motif	0.7022
p.G2010C	DO231722	LINC	ICGC	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation rewiring degron network	0.25
p.R3803Q	DO23702	LUAD	ICGC	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation rewiring degron network	0.25
p.N3791S	DO45330	LUAD	ICGC	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation rewiring degron network	0.2222
p.L3805I	DO232761	PBCA	ICGC	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation rewiring degron network	0.1944
p.G3226D	DO232224	PBCA	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation altering degron motif	0.7198
p.L3805F	DO37430	SKCM	ICGC	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation rewiring degron network	0.1944
p.D3804N	DO50281	SKCM	ICGC	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation rewiring degron network	0.2222
p.N3622H	DO40884	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	3619:3623	Mutation altering degron motif	0.7423
p.V3631L	DO40884	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	3619:3623	Mutation rewiring degron network	0.1111
p.G3221D	SIDM00422	Hodgkin's Lymphoma	GDSC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation altering degron motif	0.6087
p.G3225R	SIDM00663	Melanoma	GDSC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation altering degron motif	0.6457
p.A2726T	SIDM00232	Kidney Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	2725:2729	Mutation altering degron motif	0.6028
p.A2726T	SIDM00611	Kidney Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	2725:2729	Mutation altering degron motif	0.6028
p.A2726T	SIDM01559	Melanoma	GDSC	PASTS	DEG_SPOP_SBC_1	2725:2729	Mutation altering degron motif	0.6028
p.K3212E	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation substituting flanking lysine	0.2222
p.N2927K	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	VCTSS	DEG_SPOP_SBC_1	2935:2939	Mutation rewiring degron network	0.1111
p.R2841H	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation altering degron motif	0.7133
p.R2841H	SIDM00223	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation altering degron motif	0.7133
p.G2004E	SIDM00350	Head and Neck Carcinoma	GDSC	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation rewiring degron network	0.0833
p.S2739N	SIDM00217	Colorectal Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	2725:2729	Mutation rewiring degron network	0.0556
p.S2722P	SIDM00217	Colorectal Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	2725:2729	Mutation rewiring degron network	0.25
p.Y2020C	SIDM00261	Ewing's Sarcoma	GDSC	ACTTS	DEG_SPOP_SBC_1	2013:2017	Mutation rewiring degron network	0.25
p.E2931D	SIDM00901	Endometrial Carcinoma	GDSC	VCTSS	DEG_SPOP_SBC_1	2935:2939	Mutation rewiring degron network	0.2222
p.R2716Q	SIDM01735	Biliary Tract Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	2725:2729	Mutation rewiring degron network	0.0833
p.G2730R	SIDM01622	Breast Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	2725:2729	Mutation rewiring degron network	0.3056
p.K2935R	ACH-000543	Brain Cancer	CCLE	VCTSS	DEG_SPOP_SBC_1	2935:2939	Mutation altering degron motif	0.7237
p.H3797N	ACH-000577	Liver Cancer	CCLE	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation altering degron motif	0.7423
p.H3797N	JHH-2	liver	COSMIC	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation altering degron motif	0.7423
p.A3221V	ACH-000898	Gastric Cancer	CCLE	RGNLFGE	LIG_APCC_ABBAyCdc20_2	3220:3226	Mutation altering degron motif	0.6936
p.H3797R	ACH-000957	Colon/Colorectal Cancer	CCLE	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation altering degron motif	0.8244
p.H3797R	LS-180	large intestine	COSMIC	VSVHVD	LIG_APCC_ABBA_1	3795:3800	Mutation altering degron motif	0.8244
p.K2719R	ACH-000990	Endometrial/Uterine Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	2725:2729	Mutation rewiring degron network	0.1667
p.N2927T	ACH-000996	Endometrial/Uterine Cancer	CCLE	VCTSS	DEG_SPOP_SBC_1	2935:2939	Mutation rewiring degron network	0.1111
p.M2848V	ACH-002171	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation substituting flanking lysine	0.3333
p.M2848V	NCI-H250	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	2840:2844	Mutation substituting flanking lysine	0.3333

Kaplan plot for MYCBP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYCBP2

UniProt ID: O75592

Entrez ID: 23077

Protein name: E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Protein associated with Myc)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYCBP2 in