DegronMD

Uniprot ID: O75592

Source protein: E3 ubiquitin-protein ligase MYCBP2

Source gene: MYCBP2

Class: DEG_SCF_FBW7_1

Location: 3432:3439

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 59.475

COIL: 0.8645

CONS_SCORE: 0.4851

DSS_SCORE: 0.4905

HELIX: 0.0547

FCONS_SCORE: 1.2535

RIG_SCORE: 0.6797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D3428G	TCGA-AA-3852	COAD	TCGA	ISVTPDAS	DEG_SCF_FBW7_1	0.2222
p.R3437I	TCGA-EJ-5519	PRAD	TCGA	ISVTPDAS	DEG_SCF_FBW7_1	0.8102
p.S3440L	TCGA-ZF-AA58	BLCA	TCGA	ISVTPDAS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SCF_FBW7_1	3432:3439	ISVTPDAS	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons