DegronMD

Uniprot ID: O75592

Source protein: E3 ubiquitin-protein ligase MYCBP2

Source gene: MYCBP2

Class: DEG_SPOP_SBC_1

Location: 2013:2017

E3 ligase: SPOP

DEGRON score: 0.9844

ASA_SCORE: 60.58

COIL: 0.8008

CONS_SCORE: 0.7467

DSS_SCORE: 0.4368

HELIX: 0.0462

FCONS_SCORE: 1.1659

RIG_SCORE: 0.7004

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2013K	TCGA-AN-A046	BRCA	TCGA	ACTTS	DEG_SPOP_SBC_1	0.7022
p.E2013K	TCGA-AX-A0J0	UCEC	TCGA	ACTTS	DEG_SPOP_SBC_1	0.7022
p.D2015N	TCGA-DF-A2KU	UCEC	TCGA	ACTTS	DEG_SPOP_SBC_1	0.6932
p.E2008K	DO48439	BLCA	ICGC	ACTTS	DEG_SPOP_SBC_1	0.1944
p.E2008K	SIDM00447	B-Lymphoblastic Leukemia	GDSC	ACTTS	DEG_SPOP_SBC_1	0.1944
p.E2024Q	DO218999	BLCA	ICGC	ACTTS	DEG_SPOP_SBC_1	0.1389
p.T2016A	DO10068	COAD	ICGC	ACTTS	DEG_SPOP_SBC_1	0.7139
p.T2003K	DO228948	LICA	ICGC	ACTTS	DEG_SPOP_SBC_1	0.0556
p.T2003K	DO229015	LICA	ICGC	ACTTS	DEG_SPOP_SBC_1	0.0556
p.G2010C	DO231722	LINC	ICGC	ACTTS	DEG_SPOP_SBC_1	0.25
p.G2004E	SIDM00350	Head and Neck Carcinoma	GDSC	ACTTS	DEG_SPOP_SBC_1	0.0833
p.Y2020C	SIDM00261	Ewing's Sarcoma	GDSC	ACTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2013:2017	ACTTS	SPOP	0.9844	More...
Q9UMD9	Collagen alpha-1	DEG_SPOP_SBC_1	327:331	ACTTS	SPOP	0.945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons