DegronMD

Uniprot ID: Q9UMD9

Source protein: Collagen alpha-1

Source gene: COL17A1

Class: DEG_SPOP_SBC_1

Location: 327:331

E3 ligase: SPOP

DEGRON score: 0.945

ASA_SCORE: 66.64

COIL: 0.746

CONS_SCORE: 0.5237

DSS_SCORE: 0.2972

HELIX: 0.059

FCONS_SCORE: 0.7467

RIG_SCORE: 0.7642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N319K	DO233612	GACA	ICGC	ACTTS	DEG_SPOP_SBC_1	0.1111
p.A317T	DO220877	MELA	ICGC	ACTTS	DEG_SPOP_SBC_1	0.0556
p.T320A	SIDM01265	Plasma Cell Myeloma	GDSC	ACTTS	DEG_SPOP_SBC_1	0.1389
p.V322I	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	ACTTS	DEG_SPOP_SBC_1	0.1944
p.V322I	SIDM01695	Acute Myeloid Leukemia	GDSC	ACTTS	DEG_SPOP_SBC_1	0.1944
p.V322I	SIDM01617	Endometrial Carcinoma	GDSC	ACTTS	DEG_SPOP_SBC_1	0.1944
p.V322I	SIDM01776	Plasma Cell Myeloma	GDSC	ACTTS	DEG_SPOP_SBC_1	0.1944
p.V322I	EC-GI-10	oesophagus	COSMIC	ACTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2013:2017	ACTTS	SPOP	0.9844	More...
Q9UMD9	Collagen alpha-1	DEG_SPOP_SBC_1	327:331	ACTTS	SPOP	0.945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons