DegronMD - Q9UMD9(COL17A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1026R	TCGA-04-1342	OV	TCGA	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation rewiring degron network	0.3056
p.S374F	TCGA-19-5956	GBM	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.2778
p.S374F	TCGA-EO-A22X	UCEC	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.2778
p.S374F	DO13863	GBM	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.2778
p.S374F	DO43907	UCEC	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.2778
p.D536E	TCGA-29-2427	OV	TCGA	IGLHSD	LIG_APCC_ABBA_1	538:543	Mutation rewiring degron network	0.2778
p.D536E	TCGA-29-2427	OV	TCGA	KIGLHSD	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.3056
p.D536E	DO31594	OV	ICGC	IGLHSD	LIG_APCC_ABBA_1	538:543	Mutation rewiring degron network	0.2778
p.D536E	DO31594	OV	ICGC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.3056
p.S135N	TCGA-2W-A8YY	CESC	TCGA	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222
p.S135N	DO223732	CESC	ICGC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222
p.A373S	TCGA-44-7672	LUAD	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.3056
p.A373S	DO23576	LUAD	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.3056
p.L1031V	TCGA-55-7910	LUAD	TCGA	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation altering degron motif	0.6765
p.A376T	TCGA-61-2110	OV	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.2222
p.A376T	DO27979	OV	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.2222
p.S542C	TCGA-91-A4BC	LUAD	TCGA	IGLHSD	LIG_APCC_ABBA_1	538:543	Mutation altering degron motif	0.7541
p.S542C	TCGA-91-A4BC	LUAD	TCGA	KIGLHSD	LIG_APCC_ABBAyCdc20_2	537:543	Mutation altering degron motif	0.7541
p.S542C	DO45422	LUAD	ICGC	IGLHSD	LIG_APCC_ABBA_1	538:543	Mutation altering degron motif	0.7541
p.S542C	DO45422	LUAD	ICGC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	537:543	Mutation altering degron motif	0.7541
p.P375T	TCGA-95-A4VN	LUAD	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.25
p.P375T	DO51199	LUAD	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.25
p.K369N	TCGA-A5-A0G2	UCEC	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation altering degron motif	0.5806
p.K369N	DO41235	UCEC	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation altering degron motif	0.5806
p.M363I	TCGA-AC-A4ZE	BRCA	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.25
p.M363I	DO223930	BRCA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.25
p.F126V	TCGA-AP-A056	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.F126V	DO43971	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.S128Y	TCGA-AX-A2HC	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.712
p.S128Y	DO41572	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.712
p.E139D	TCGA-BF-A1PZ	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.E139D	DO50279	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.S79G	TCGA-BK-A0C9	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	75:79	Mutation altering degron motif	0.8104
p.S79G	DO41253	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	75:79	Mutation altering degron motif	0.8104
p.Q1035H	TCGA-EE-A29G	SKCM	TCGA	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation altering degron motif	0.647
p.Q1035H	DO47303	SKCM	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation altering degron motif	0.647
p.G532R	TCGA-EE-A3AA	SKCM	TCGA	IGLHSD	LIG_APCC_ABBA_1	538:543	Mutation rewiring degron network	0.1667
p.G532R	TCGA-EE-A3AA	SKCM	TCGA	KIGLHSD	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.1944
p.G532R	DO222632	MELA	ICGC	IGLHSD	LIG_APCC_ABBA_1	538:543	Mutation rewiring degron network	0.1667
p.G532R	DO222632	MELA	ICGC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.1944
p.G532R	DO37571	SKCM	ICGC	IGLHSD	LIG_APCC_ABBA_1	538:543	Mutation rewiring degron network	0.1667
p.G532R	DO37571	SKCM	ICGC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.1944
p.P122T	TCGA-G4-6588	COAD	TCGA	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.P122T	DO10140	COAD	ICGC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.E357K	TCGA-GN-A266	SKCM	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.0833
p.E357K	DO37432	SKCM	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.0833
p.D536N	TCGA-IR-A3LL	CESC	TCGA	IGLHSD	LIG_APCC_ABBA_1	538:543	Mutation rewiring degron network	0.2778
p.D536N	TCGA-IR-A3LL	CESC	TCGA	KIGLHSD	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.3056
p.D536N	DO44362	CESC	ICGC	IGLHSD	LIG_APCC_ABBA_1	538:543	Mutation rewiring degron network	0.2778
p.D536N	DO44362	CESC	ICGC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.3056
p.I362M	TCGA-PE-A5DE	BRCA	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.2222
p.I362M	DO219643	BRCA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.2222
p.S382C	TCGA-XF-A8HF	BLCA	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.0556
p.S382C	DO49800	BLCA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.0556
p.G1033R	DO224869	BRCA	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation altering degron motif	0.6457
p.G1033R	DO228390	LICA	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation altering degron motif	0.6457
p.A83D	DO223469	CLLE	ICGC	ASTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2222
p.S1032P	DO222884	COCA	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation altering degron motif	0.5641
p.N319K	DO233612	GACA	ICGC	ACTTS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1111
p.S118F	DO228963	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0833
p.S367R	DO228976	LICA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation altering degron motif	0.8538
p.S377R	DO229029	LICA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.1944
p.A380E	DO229037	LICA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.1111
p.A317T	DO220877	MELA	ICGC	ACTTS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.E125K	DO222363	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.G1027R	DO222632	MELA	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation altering degron motif	0.7568
p.S130L	DO229459	SKCA	ICGC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.8778
p.R1024W	DO52426	UCEC	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation rewiring degron network	0.25
p.T320A	SIDM01265	Plasma Cell Myeloma	GDSC	ACTTS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1389
p.A376V	SIDM00683	Prostate Carcinoma	GDSC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.2222
p.A376V	ACH-000977	lymph node	CCLE	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.2222
p.A376V	LNCaP-Clone-FGC	prostate	COSMIC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.2222
p.R132T	SIDM00234	Other Solid Cancers	GDSC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.R132T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.S1029A	SIDM01197	Colorectal Carcinoma	GDSC	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation altering degron motif	0.6477
p.S1029A	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation altering degron motif	0.6477
p.S1029A	SIDM00531	Pancreatic Carcinoma	GDSC	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation altering degron motif	0.6477
p.S1029A	SIDM01442	Glioma	GDSC	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation altering degron motif	0.6477
p.A127E	SIDM01002	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7701
p.A127E	EFM-192A	breast	COSMIC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7701
p.G73D	SIDM00193	Colorectal Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2778
p.G73D	ACH-000991	Colon/Colorectal Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2778
p.G73D	SNU-81	large intestine	COSMIC	ASTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.2778
p.V322I	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	ACTTS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.V322I	SIDM01695	Acute Myeloid Leukemia	GDSC	ACTTS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.V322I	SIDM01617	Endometrial Carcinoma	GDSC	ACTTS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.V322I	SIDM01776	Plasma Cell Myeloma	GDSC	ACTTS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.V322I	EC-GI-10	oesophagus	COSMIC	ACTTS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.P119L	SIDM00487	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.P119L	ACH-000963	Colon/Colorectal Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.P119L	CCK-81	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1111
p.H74R	SIDM00397	Acute Myeloid Leukemia	GDSC	ASTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.3056
p.H74R	ACH-000195	Leukemia	CCLE	ASTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.3056
p.H74R	Set2	haematopoietic and lymphoid tissue	COSMIC	ASTSS	DEG_SPOP_SBC_1	75:79	Mutation rewiring degron network	0.3056
p.L540M	SIDM00785	Acute Myeloid Leukemia	GDSC	IGLHSD	LIG_APCC_ABBA_1	538:543	Mutation altering degron motif	0.5999
p.L540M	SIDM00785	Acute Myeloid Leukemia	GDSC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	537:543	Mutation altering degron motif	0.5999
p.A380T	SIDM00785	Acute Myeloid Leukemia	GDSC	DSGKVFT	DEG_SCF_TRCP1_1	366:372	Mutation rewiring degron network	0.1111
p.Y80S	ACH-001795	Liposarcoma	CCLE	ASTSS	DEG_SPOP_SBC_1	75:79	Mutation blocking phosphorylation signal	0.75
p.Y80D	ACH-001795	Liposarcoma	CCLE	ASTSS	DEG_SPOP_SBC_1	75:79	Mutation blocking phosphorylation signal	0.75
p.P1043S	ACH-002288	Embryonal Cancer	CCLE	IRSYLSGVQ	DEG_APCC_DBOX_1	1027:1035	Mutation rewiring degron network	0.1111
p.R123W	ACH-002348	Non-Cancerous	CCLE	ASSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL17A1

UniProt ID: Q9UMD9

Entrez ID: 1308

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL17A1 in