DegronMD

Uniprot ID: Q9UMD9

Source protein: Collagen alpha-1

Source gene: COL17A1

Class: LIG_APCC_ABBA_1

Location: 538:543

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9931

ASA_SCORE: 71.7833

COIL: 0.7908

CONS_SCORE: 0.4052

DSS_SCORE: 0.3687

HELIX: 0.1497

FCONS_SCORE: 0.8574

RIG_SCORE: 0.7157

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D536E	TCGA-29-2427	OV	TCGA	IGLHSD	LIG_APCC_ABBA_1	0.2778
p.D536E	DO31594	OV	ICGC	IGLHSD	LIG_APCC_ABBA_1	0.2778
p.S542C	TCGA-91-A4BC	LUAD	TCGA	IGLHSD	LIG_APCC_ABBA_1	0.7541
p.S542C	DO45422	LUAD	ICGC	IGLHSD	LIG_APCC_ABBA_1	0.7541
p.G532R	TCGA-EE-A3AA	SKCM	TCGA	IGLHSD	LIG_APCC_ABBA_1	0.1667
p.G532R	DO222632	MELA	ICGC	IGLHSD	LIG_APCC_ABBA_1	0.1667
p.G532R	DO37571	SKCM	ICGC	IGLHSD	LIG_APCC_ABBA_1	0.1667
p.D536N	TCGA-IR-A3LL	CESC	TCGA	IGLHSD	LIG_APCC_ABBA_1	0.2778
p.D536N	DO44362	CESC	ICGC	IGLHSD	LIG_APCC_ABBA_1	0.2778
p.L540M	SIDM00785	Acute Myeloid Leukemia	GDSC	IGLHSD	LIG_APCC_ABBA_1	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMD9	Collagen alpha-1	LIG_APCC_ABBA_1	538:543	IGLHSD	APC,CDC20,FZR1	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons