DegronMD

Uniprot ID: Q9UMD9

Source protein: Collagen alpha-1

Source gene: COL17A1

Class: DEG_APCC_DBOX_1

Location: 1027:1035

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9509

ASA_SCORE: 77.0333

COIL: 0.8527

CONS_SCORE: 0.7166

DSS_SCORE: 0.6685

HELIX: 0.0796

FCONS_SCORE: 1.0203

RIG_SCORE: 0.6577

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1026R	TCGA-04-1342	OV	TCGA	IRSYLSGVQ	DEG_APCC_DBOX_1	0.3056
p.L1031V	TCGA-55-7910	LUAD	TCGA	IRSYLSGVQ	DEG_APCC_DBOX_1	0.6765
p.Q1035H	TCGA-EE-A29G	SKCM	TCGA	IRSYLSGVQ	DEG_APCC_DBOX_1	0.647
p.Q1035H	DO47303	SKCM	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	0.647
p.G1033R	DO224869	BRCA	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	0.6457
p.G1033R	DO228390	LICA	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	0.6457
p.S1032P	DO222884	COCA	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	0.5641
p.G1027R	DO222632	MELA	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	0.7568
p.R1024W	DO52426	UCEC	ICGC	IRSYLSGVQ	DEG_APCC_DBOX_1	0.25
p.S1029A	SIDM01197	Colorectal Carcinoma	GDSC	IRSYLSGVQ	DEG_APCC_DBOX_1	0.6477
p.S1029A	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	IRSYLSGVQ	DEG_APCC_DBOX_1	0.6477
p.S1029A	SIDM00531	Pancreatic Carcinoma	GDSC	IRSYLSGVQ	DEG_APCC_DBOX_1	0.6477
p.S1029A	SIDM01442	Glioma	GDSC	IRSYLSGVQ	DEG_APCC_DBOX_1	0.6477
p.P1043S	ACH-002288	Embryonal Cancer	CCLE	IRSYLSGVQ	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMD9	Collagen alpha-1	DEG_APCC_DBOX_1	1027:1035	IRSYLSGVQ	APC,CDC20,FZR1	0.9509	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons