DegronMD

Uniprot ID: Q9UMD9

Source protein: Collagen alpha-1

Source gene: COL17A1

Class: LIG_APCC_ABBAyCdc20_2

Location: 537:543

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9837

ASA_SCORE: 78.9714

COIL: 0.7607

CONS_SCORE: 0.4146

DSS_SCORE: 0.3863

HELIX: 0.1814

FCONS_SCORE: 0.8763

RIG_SCORE: 0.7188

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D536E	TCGA-29-2427	OV	TCGA	KIGLHSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D536E	DO31594	OV	ICGC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S542C	TCGA-91-A4BC	LUAD	TCGA	KIGLHSD	LIG_APCC_ABBAyCdc20_2	0.7541
p.S542C	DO45422	LUAD	ICGC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	0.7541
p.G532R	TCGA-EE-A3AA	SKCM	TCGA	KIGLHSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G532R	DO222632	MELA	ICGC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G532R	DO37571	SKCM	ICGC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D536N	TCGA-IR-A3LL	CESC	TCGA	KIGLHSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D536N	DO44362	CESC	ICGC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L540M	SIDM00785	Acute Myeloid Leukemia	GDSC	KIGLHSD	LIG_APCC_ABBAyCdc20_2	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMD9	Collagen alpha-1	LIG_APCC_ABBAyCdc20_2	537:543	KIGLHSD	APC,CDC20,FZR1	0.9837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons