DegronMD

Uniprot ID: Q9UMD9

Source protein: Collagen alpha-1

Source gene: COL17A1

Class: DEG_SCF_TRCP1_1

Location: 366:372

E3 ligase: BTRC

DEGRON score: 0.8707

ASA_SCORE: 76.5143

COIL: 0.6746

CONS_SCORE: 0.9046

DSS_SCORE: 0.2562

HELIX: 0.0409

FCONS_SCORE: 1.2177

RIG_SCORE: 0.7526

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S374F	TCGA-19-5956	GBM	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	0.2778
p.S374F	TCGA-EO-A22X	UCEC	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	0.2778
p.S374F	DO13863	GBM	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.2778
p.S374F	DO43907	UCEC	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.2778
p.A373S	TCGA-44-7672	LUAD	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	0.3056
p.A373S	DO23576	LUAD	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.3056
p.A376T	TCGA-61-2110	OV	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	0.2222
p.A376T	DO27979	OV	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.2222
p.P375T	TCGA-95-A4VN	LUAD	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	0.25
p.P375T	DO51199	LUAD	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.25
p.K369N	TCGA-A5-A0G2	UCEC	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	0.5806
p.K369N	DO41235	UCEC	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.5806
p.M363I	TCGA-AC-A4ZE	BRCA	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	0.25
p.M363I	DO223930	BRCA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.25
p.E357K	TCGA-GN-A266	SKCM	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	0.0833
p.E357K	DO37432	SKCM	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.0833
p.I362M	TCGA-PE-A5DE	BRCA	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	0.2222
p.I362M	DO219643	BRCA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.2222
p.S382C	TCGA-XF-A8HF	BLCA	TCGA	DSGKVFT	DEG_SCF_TRCP1_1	0.0556
p.S382C	DO49800	BLCA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.0556
p.S367R	DO228976	LICA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.8538
p.S377R	DO229029	LICA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.1944
p.A380E	DO229037	LICA	ICGC	DSGKVFT	DEG_SCF_TRCP1_1	0.1111
p.A376V	SIDM00683	Prostate Carcinoma	GDSC	DSGKVFT	DEG_SCF_TRCP1_1	0.2222
p.A376V	ACH-000977	lymph_node	CCLE	DSGKVFT	DEG_SCF_TRCP1_1	0.2222
p.A376V	LNCaP-Clone-FGC	prostate	COSMIC	DSGKVFT	DEG_SCF_TRCP1_1	0.2222
p.A380T	SIDM00785	Acute Myeloid Leukemia	GDSC	DSGKVFT	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMD9	Collagen alpha-1	DEG_SCF_TRCP1_1	366:372	DSGKVFT	BTRC	0.8707	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGKVFT

Degron related mutations and impact score

Drug responses associated with COL17A1 mutations

All proteins holding degron of DSGKVFT