DegronMD

Uniprot ID: O75592

Source protein: E3 ubiquitin-protein ligase MYCBP2

Source gene: MYCBP2

Class: DEG_SPOP_SBC_1

Location: 2935:2939

E3 ligase: SPOP

DEGRON score: 0.988

ASA_SCORE: 81.4

COIL: 0.7804

CONS_SCORE: 0.3067

DSS_SCORE: 0.4277

HELIX: 0.1208

FCONS_SCORE: 1.0745

RIG_SCORE: 0.7856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2948L	TCGA-A5-A0G2	UCEC	TCGA	VCTSS	DEG_SPOP_SBC_1	0.0833
p.N2927K	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	VCTSS	DEG_SPOP_SBC_1	0.1111
p.E2931D	SIDM00901	Endometrial Carcinoma	GDSC	VCTSS	DEG_SPOP_SBC_1	0.2222
p.K2935R	ACH-000543	Brain Cancer	CCLE	VCTSS	DEG_SPOP_SBC_1	0.7237
p.N2927T	ACH-000996	Endometrial/Uterine Cancer	CCLE	VCTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60296	Trafficking kinesin-binding protein 2	DEG_SPOP_SBC_1	901:905	VCTSS	SPOP	0.7725	More...
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2935:2939	VCTSS	SPOP	0.988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons