DegronMD

Uniprot ID: O75592

Source protein: E3 ubiquitin-protein ligase MYCBP2

Source gene: MYCBP2

Class: DEG_APCC_KENBOX_2

Location: 3619:3623

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9101

ASA_SCORE: 100.36

COIL: 0.5254

CONS_SCORE: 0.6541

DSS_SCORE: 0.7639

HELIX: 0.467

FCONS_SCORE: 1.2409

RIG_SCORE: 0.6254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3623L	TCGA-66-2778	LUSC	TCGA	SKENS	DEG_APCC_KENBOX_2	0.6556
p.H3616Y	TCGA-A8-A095	BRCA	TCGA	SKENS	DEG_APCC_KENBOX_2	0.25
p.R3617C	TCGA-AG-A002	READ	TCGA	SKENS	DEG_APCC_KENBOX_2	0.2778
p.N3616K	DO21235	LAML	ICGC	SKENS	DEG_APCC_KENBOX_2	0.25
p.N3616K	DO28281	OV	ICGC	SKENS	DEG_APCC_KENBOX_2	0.25
p.E3612D	DO22237	LGG	ICGC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.T3618K	DO229031	LICA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.3056
p.E3621K	DO219565	LIHC	ICGC	SKENS	DEG_APCC_KENBOX_2	0.7022
p.N3622H	DO40884	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	0.7423
p.V3631L	DO40884	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_APCC_KENBOX_2	3619:3623	SKENS	APC,CDC20,FZR1	0.9101	More...
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_APCC_KENBOX_2	704:708	SKENS	APC,CDC20,FZR1	0.6409	More...
Q5FWF5	N-acetyltransferase ESCO1	DEG_APCC_KENBOX_2	8:12	SKENS	APC,CDC20,FZR1	0.9682	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_APCC_KENBOX_2	215:219	SKENS	APC,CDC20,FZR1	0.996	More...
Q5BJE1	Coiled-coil domain-containing protein 178	DEG_APCC_KENBOX_2	53:57	SKENS	APC,CDC20,FZR1	0.8419	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons