DegronMD

Uniprot ID: Q5FWF5

Source protein: N-acetyltransferase ESCO1

Source gene: ESCO1

Class: DEG_APCC_KENBOX_2

Location: 8:12

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9682

ASA_SCORE: 107.04

COIL: 0.8354

CONS_SCORE: 0.3127

DSS_SCORE: 0.7261

HELIX: 0.1532

FCONS_SCORE: 1.0502

RIG_SCORE: 0.6063

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E6D	TCGA-AP-A1E0	UCEC	TCGA	SKENS	DEG_APCC_KENBOX_2	0.2778
p.E6D	TCGA-F5-6814	READ	TCGA	SKENS	DEG_APCC_KENBOX_2	0.2778
p.E6D	DO36556	READ	ICGC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.E6D	DO43154	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.E10D	TCGA-B5-A0JY	UCEC	TCGA	SKENS	DEG_APCC_KENBOX_2	0.6758
p.E10D	DO43041	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	0.6758
p.S12A	DO232852	NACA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.6477
p.S8A	DO47156	RECA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.6477
p.S19T	SIDM00582	Pancreatic Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM00602	Gastric Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM01242	Melanoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM00465	Ovarian Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM00581	Glioblastoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM00589	Oral Cavity Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM00492	Glioblastoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM00290	Gastric Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM00502	B-Lymphoblastic Leukemia	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM01033	Bladder Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SIDM01619	Endometrial Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	HSC-3	upper_aerodigestive_tract	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	HGC-27	stomach	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	KP-2	pancreas	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	AM-38	central_nervous_system	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	GB-1	central_nervous_system	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	KU-19-19	urinary_tract	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	IM-95	stomach	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	KYSE-520	oesophagus	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	MMAC-SF	skin	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S19T	OVMIU	ovary	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S8L	SIDM01198	Burkitt's Lymphoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.6556
p.S8L	ACH-000567	Lymphoma	CCLE	SKENS	DEG_APCC_KENBOX_2	0.6556
p.S8L	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.6556
p.K18R	SIDM00315	Glioblastoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.K18R	SIDM00165	Other Solid Cancers	GDSC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.K18R	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.K18R	YKG-1	central_nervous_system	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.K22N	SIDM00118	Colorectal Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1667
p.K22N	ACH-001081	Colon/Colorectal Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	0.1667
p.K22N	HCC2998	large_intestine	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1667
p.K22R	SIDM00760	Small Cell Lung Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1667
p.K22R	ACH-000729	Lung Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	0.1667
p.K22R	NCI-H1963	lung	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1667
p.K14N	SIDM01611	Endometrial Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.K14N	ACH-000996	Endometrial/Uterine Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	0.2778
p.S19G	ACH-000566	Bladder Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	0.1389
p.E16K	HCC2998	large_intestine	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_APCC_KENBOX_2	3619:3623	SKENS	APC,CDC20,FZR1	0.9101	More...
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_APCC_KENBOX_2	704:708	SKENS	APC,CDC20,FZR1	0.6409	More...
Q5FWF5	N-acetyltransferase ESCO1	DEG_APCC_KENBOX_2	8:12	SKENS	APC,CDC20,FZR1	0.9682	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_APCC_KENBOX_2	215:219	SKENS	APC,CDC20,FZR1	0.996	More...
Q5BJE1	Coiled-coil domain-containing protein 178	DEG_APCC_KENBOX_2	53:57	SKENS	APC,CDC20,FZR1	0.8419	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENS

Degron related mutations and impact score

Drug responses associated with ESCO1 mutations

All proteins holding degron of SKENS