DegronMD - Q5BJE1(CCDC178)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q16K	TCGA-05-4410	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1944
p.Q16K	DO25426	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1944
p.K54M	TCGA-17-Z055	LUAD	TCGA	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation altering degron motif	0.8062
p.V7F	TCGA-35-5375	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7068
p.V7F	DO25290	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7068
p.T12I	TCGA-97-7937	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.T12I	DO25649	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.T66A	TCGA-A5-A2K3	UCEC	TCGA	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.0833
p.T66A	TCGA-AP-A1DV	UCEC	TCGA	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.0833
p.T66A	DO43186	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.0833
p.T66A	DO43899	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.0833
p.D14N	TCGA-B1-A657	KIRP	TCGA	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.25
p.D14N	DO51552	KIRP	ICGC	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.25
p.T2N	TCGA-BS-A0UV	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation substituting flanking lysine	0.3056
p.T2N	DO42793	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation substituting flanking lysine	0.3056
p.K54N	TCGA-DA-A1I0	SKCM	TCGA	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation altering degron motif	0.6918
p.K54N	DO37719	SKCM	ICGC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation altering degron motif	0.6918
p.D15Y	TCGA-F5-6814	READ	TCGA	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.D15Y	DO36556	READ	ICGC	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.S11F	TCGA-FW-A3R5	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7982
p.S11F	DO37406	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7982
p.G20C	TCGA-HE-7128	KIRP	TCGA	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.0833
p.G20C	DO20796	KIRP	ICGC	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.0833
p.H61Y	TCGA-SY-A9G5	BLCA	TCGA	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.2222
p.H61Y	DO51906	BLCA	ICGC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.2222
p.M43L	TCGA-XF-A9SU	BLCA	TCGA	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.0556
p.M43L	DO223600	BLCA	ICGC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.0556
p.Q45E	DO228562	LICA	ICGC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.1111
p.Q45E	DO228807	LICA	ICGC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.1111
p.N4Y	DO50974	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.25
p.K54T	DO220866	MELA	ICGC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation altering degron motif	0.7306
p.G51R	DO222908	MELA	ICGC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.2778
p.G59S	DO232761	PBCA	ICGC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.2778
p.E3V	SIDM01592	Breast Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.E3V	ACH-000134	Non-Cancerous	CCLE	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.S46R	SIDM01473	Plasma Cell Myeloma	GDSC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.1389
p.S46R	ACH-000541	Myeloma	CCLE	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.1389
p.M65I	ACH-002396	Bone Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.1111
p.M65I	Sarc9371	bone	COSMIC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.1111
p.E15K	MCC13	skin	COSMIC	VSSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.E47K	KYSE-180	oesophagus	COSMIC	SKENS	DEG_APCC_KENBOX_2	53:57	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC178

UniProt ID: Q5BJE1

Entrez ID: 374864

Protein name: Coiled-coil domain-containing protein 178

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC178 in