DegronMD

Uniprot ID: Q5BJE1

Source protein: Coiled-coil domain-containing protein 178

Source gene: CCDC178

Class: DEG_APCC_KENBOX_2

Location: 53:57

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8419

ASA_SCORE: 95.86

COIL: 0.7286

CONS_SCORE: 0.2957

DSS_SCORE: 0.4069

HELIX: 0.2414

FCONS_SCORE: 0.9863

RIG_SCORE: 0.643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K54M	TCGA-17-Z055	LUAD	TCGA	SKENS	DEG_APCC_KENBOX_2	0.8062
p.T66A	TCGA-A5-A2K3	UCEC	TCGA	SKENS	DEG_APCC_KENBOX_2	0.0833
p.T66A	TCGA-AP-A1DV	UCEC	TCGA	SKENS	DEG_APCC_KENBOX_2	0.0833
p.T66A	DO43186	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	0.0833
p.T66A	DO43899	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	0.0833
p.K54N	TCGA-DA-A1I0	SKCM	TCGA	SKENS	DEG_APCC_KENBOX_2	0.6918
p.K54N	DO37719	SKCM	ICGC	SKENS	DEG_APCC_KENBOX_2	0.6918
p.H61Y	TCGA-SY-A9G5	BLCA	TCGA	SKENS	DEG_APCC_KENBOX_2	0.2222
p.H61Y	DO51906	BLCA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.2222
p.M43L	TCGA-XF-A9SU	BLCA	TCGA	SKENS	DEG_APCC_KENBOX_2	0.0556
p.M43L	DO223600	BLCA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.0556
p.Q45E	DO228562	LICA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.1111
p.Q45E	DO228807	LICA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.1111
p.K54T	DO220866	MELA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.7306
p.G51R	DO222908	MELA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.G59S	DO232761	PBCA	ICGC	SKENS	DEG_APCC_KENBOX_2	0.2778
p.S46R	SIDM01473	Plasma Cell Myeloma	GDSC	SKENS	DEG_APCC_KENBOX_2	0.1389
p.S46R	ACH-000541	Myeloma	CCLE	SKENS	DEG_APCC_KENBOX_2	0.1389
p.M65I	ACH-002396	Bone Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	0.1111
p.M65I	Sarc9371	bone	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1111
p.E47K	KYSE-180	oesophagus	COSMIC	SKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_APCC_KENBOX_2	3619:3623	SKENS	APC,CDC20,FZR1	0.9101	More...
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_APCC_KENBOX_2	704:708	SKENS	APC,CDC20,FZR1	0.6409	More...
Q5FWF5	N-acetyltransferase ESCO1	DEG_APCC_KENBOX_2	8:12	SKENS	APC,CDC20,FZR1	0.9682	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_APCC_KENBOX_2	215:219	SKENS	APC,CDC20,FZR1	0.996	More...
Q5BJE1	Coiled-coil domain-containing protein 178	DEG_APCC_KENBOX_2	53:57	SKENS	APC,CDC20,FZR1	0.8419	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons