DegronMD - O94966(USP19)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R935Q	TCGA-2W-A8YY	CESC	TCGA	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.25
p.R446C	TCGA-59-2349	OV	TCGA	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation blocking phosphorylation signal	0.6389
p.R707H	TCGA-5M-AAT6	COAD	TCGA	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.8244
p.R707H	TCGA-AA-A01R	COAD	TCGA	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.8244
p.R707H	TCGA-AP-A1DV	UCEC	TCGA	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.8244
p.R707H	SIDM00217	Colorectal Carcinoma	GDSC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.8244
p.R707H	ACH-000999	Colon/Colorectal Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.8244
p.R707H	SNU-1040	large intestine	COSMIC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.8244
p.H442N	TCGA-85-8582	LUSC	TCGA	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.0833
p.H106D	TCGA-AC-A23H	BRCA	TCGA	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.2778
p.H106D	DO2401	BRCA	ICGC	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.2778
p.E458D	TCGA-AP-A059	UCEC	TCGA	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.2778
p.F943L	TCGA-B9-5155	KIRP	TCGA	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.3056
p.R911L	TCGA-BA-6869	HNSC	TCGA	LVTPMAE	DEG_SCF_FBW7_2	915:921	Mutation rewiring degron network	0.2222
p.C463Y	TCGA-BD-A2L6	LIHC	TCGA	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation substituting flanking lysine	0.25
p.L697M	TCGA-CV-7415	HNSC	TCGA	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.1389
p.C922R	TCGA-DI-A1BU	UCEC	TCGA	LVTPMAE	DEG_SCF_FBW7_2	915:921	Mutation rewiring degron network	0.3056
p.H926N	TCGA-EE-A2M6	SKCM	TCGA	LVTPMAE	DEG_SCF_FBW7_2	915:921	Mutation rewiring degron network	0.1944
p.G700W	TCGA-EE-A2MD	SKCM	TCGA	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2222
p.P105S	TCGA-EE-A2MT	SKCM	TCGA	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.25
p.P105S	DO38051	SKCM	ICGC	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.25
p.D704A	TCGA-EE-A3AB	SKCM	TCGA	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.7793
p.G700E	TCGA-EO-A22U	UCEC	TCGA	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2222
p.G100E	TCGA-EO-A22U	UCEC	TCGA	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.1111
p.G100E	DO43755	UCEC	ICGC	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.1111
p.H106N	TCGA-ER-A1A1	SKCM	TCGA	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.2778
p.H106N	DO37413	SKCM	ICGC	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.2778
p.K711T	TCGA-VQ-A8E3	STAD	TCGA	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.25
p.S111F	DO51886	BLCA	ICGC	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation altering degron motif	0.7982
p.Y906C	DO8634	COAD	ICGC	LVTPMAE	DEG_SCF_FBW7_2	915:921	Mutation rewiring degron network	0.0833
p.L710I	DO8264	COAD	ICGC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.L710I	DO41133	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.R118C	DO233207	GACA	ICGC	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.25
p.Q949K	DO14830	HNSC	ICGC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1389
p.P112H	DO228976	LICA	ICGC	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation altering degron motif	0.7694
p.P443T	DO228971	LICA	ICGC	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.1111
p.P105T	DO229028	LICA	ICGC	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.25
p.D946E	DO229037	LICA	ICGC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2222
p.P708A	DO22938	LIHC	ICGC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.7503
p.Y105S	DO231762	LINC	ICGC	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.25
p.T931A	DO26617	LUSC	ICGC	LVTPMAE	DEG_SCF_FBW7_2	915:921	Mutation rewiring degron network	0.0556
p.T931A	DO26617	LUSC	ICGC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1389
p.E461K	DO45515	LUSC	ICGC	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation blocking phosphorylation signal	0.6389
p.L716F	DO32904	PACA	ICGC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.1111
p.T935A	DO35394	PACA	ICGC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.25
p.D445N	DO37130	READ	ICGC	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.1667
p.L710F	DO218849	SKCA	ICGC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.P947S	DO37839	SKCM	ICGC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1944
p.P947H	DO47613	SKCM	ICGC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1944
p.G928V	DO38887	STAD	ICGC	LVTPMAE	DEG_SCF_FBW7_2	915:921	Mutation rewiring degron network	0.1389
p.G928V	DO38887	STAD	ICGC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.0556
p.R919H	DO38336	STAD	ICGC	LVTPMAE	DEG_SCF_FBW7_2	915:921	Mutation altering degron motif	0.8244
p.P708L	DO219764	UCEC	ICGC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.7582
p.R945I	DO43306	UCEC	ICGC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.25
p.E944G	DO43891	UCEC	ICGC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2778
p.T716I	SIDM01175	Other Sarcomas	GDSC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.1111
p.T716I	ACH-002309	Sarcoma	CCLE	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.1111
p.T716I	SW684	soft tissue	COSMIC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.1111
p.V449L	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.2778
p.V449L	ACH-000860	Lung Cancer	CCLE	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.2778
p.V449L	NCI-H358	lung	COSMIC	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.2778
p.N710K	SIDM00795	Melanoma	GDSC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.N710K	ACH-000219	Skin Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.N710K	ACH-002001	Skin Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.N710K	ACH-002002	Skin Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.N710K	ACH-002003	Skin Cancer	CCLE	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.N710K	A375	skin	COSMIC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.E944D	KYSE-180	oesophagus	COSMIC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2778
p.T706I	SW684	soft tissue	COSMIC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.7078
p.A710V	KP-2	pancreas	COSMIC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2778
p.M919K	NCI-H650	lung	COSMIC	LVTPMAE	DEG_SCF_FBW7_2	915:921	Mutation altering degron motif	0.6951
p.T452N	T84	large intestine	COSMIC	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation altering degron motif	0.8166
p.Y941S	KARPAS-299	haematopoietic and lymphoid tissue	COSMIC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation altering degron motif	0.712
p.H124Y	SNU-175	large intestine	COSMIC	LLATPTPE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.0833
p.Y943S	KARPAS-299	haematopoietic and lymphoid tissue	COSMIC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.3056
p.P447T	HCT-15	large intestine	COSMIC	VTPKPE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.2222
p.N700K	A375	skin	COSMIC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2222
p.Y931S	KARPAS-299	haematopoietic and lymphoid tissue	COSMIC	LVTPMAE	DEG_SCF_FBW7_2	915:921	Mutation rewiring degron network	0.0556
p.Y931S	KARPAS-299	haematopoietic and lymphoid tissue	COSMIC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1389
p.R697H	SNU-1040	large intestine	COSMIC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.1389
p.D707Y	42-MG-BA	central nervous system	COSMIC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation altering degron motif	0.7325
p.P939S	SNU-407	large intestine	COSMIC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation altering degron motif	0.5641
p.T718I	SW684	soft tissue	COSMIC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.0556
p.R709H	SNU-1040	large intestine	COSMIC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.3056
p.P933S	Mewo	skin	COSMIC	VPSTS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1944
p.N712K	A375	skin	COSMIC	SKENS	DEG_APCC_KENBOX_2	704:708	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP19

UniProt ID: O94966

Entrez ID: 10869

Protein name: Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP19 in