DegronMD

Uniprot ID: O94966

Source protein: Ubiquitin carboxyl-terminal hydrolase 19

Source gene: USP19

Class: DEG_SPOP_SBC_1

Location: 938:942

E3 ligase: SPOP

DEGRON score: 0.9914

ASA_SCORE: 72.28

COIL: 0.87

CONS_SCORE: 0.2679

DSS_SCORE: 0.5685

HELIX: 0.0528

FCONS_SCORE: 1.0779

RIG_SCORE: 0.6366

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R935Q	TCGA-2W-A8YY	CESC	TCGA	VPSTS	DEG_SPOP_SBC_1	0.25
p.F943L	TCGA-B9-5155	KIRP	TCGA	VPSTS	DEG_SPOP_SBC_1	0.3056
p.Q949K	DO14830	HNSC	ICGC	VPSTS	DEG_SPOP_SBC_1	0.1389
p.D946E	DO229037	LICA	ICGC	VPSTS	DEG_SPOP_SBC_1	0.2222
p.T931A	DO26617	LUSC	ICGC	VPSTS	DEG_SPOP_SBC_1	0.1389
p.T935A	DO35394	PACA	ICGC	VPSTS	DEG_SPOP_SBC_1	0.25
p.P947S	DO37839	SKCM	ICGC	VPSTS	DEG_SPOP_SBC_1	0.1944
p.P947H	DO47613	SKCM	ICGC	VPSTS	DEG_SPOP_SBC_1	0.1944
p.G928V	DO38887	STAD	ICGC	VPSTS	DEG_SPOP_SBC_1	0.0556
p.R945I	DO43306	UCEC	ICGC	VPSTS	DEG_SPOP_SBC_1	0.25
p.E944G	DO43891	UCEC	ICGC	VPSTS	DEG_SPOP_SBC_1	0.2778
p.E944D	KYSE-180	oesophagus	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.2778
p.Y941S	KARPAS-299	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.712
p.Y943S	KARPAS-299	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.3056
p.Y931S	KARPAS-299	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.1389
p.P939S	SNU-407	large_intestine	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.5641
p.P933S	Mewo	skin	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_SPOP_SBC_1	938:942	VPSTS	SPOP	0.9914	More...
O95665	Neurotensin receptor type 2	DEG_SPOP_SBC_1	240:244	VPSTS	SPOP	0.8867	More...
P24386	Rab proteins geranylgeranyltransferase component A 1	DEG_SPOP_SBC_1	188:192	VPSTS	SPOP	0.9827	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4260:4264	VPSTS	SPOP	0.9795	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_SPOP_SBC_1	2123:2127	VPSTS	SPOP	0.9469	More...
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SPOP_SBC_1	777:781	VPSTS	SPOP	0.9965	More...
Q86WV6	Stimulator of interferon genes protein	DEG_SPOP_SBC_1	351:355	VPSTS	SPOP	0.9975	More...
Q92574	Hamartin	DEG_SPOP_SBC_1	640:644	VPSTS	SPOP	0.9829	More...
Q92772	Cyclin-dependent kinase-like 2	DEG_SPOP_SBC_1	389:393	VPSTS	SPOP	0.9663	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	192:196	VPSTS	SPOP	0.993	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	159:163	VPSTS	SPOP	0.9657	More...
Q8TBF4	Zinc finger CCHC-type and RNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	191:195	VPSTS	SPOP	0.989	More...
P0C6C1	Ankyrin repeat domain-containing protein 34C	DEG_SPOP_SBC_1	426:430	VPSTS	SPOP	0.9869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons