DegronMD

Uniprot ID: Q92772

Source protein: Cyclin-dependent kinase-like 2

Source gene: CDKL2

Class: DEG_SPOP_SBC_1

Location: 389:393

E3 ligase: SPOP

DEGRON score: 0.9663

ASA_SCORE: 77.9

COIL: 0.897

CONS_SCORE: 0.3716

DSS_SCORE: 0.4775

HELIX: 0.0706

FCONS_SCORE: 0.883

RIG_SCORE: 0.6815

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H385Y	TCGA-D5-6540	COAD	TCGA	VPSTS	DEG_SPOP_SBC_1	0.2222
p.H385Y	DO9708	COAD	ICGC	VPSTS	DEG_SPOP_SBC_1	0.2222
p.V402M	TCGA-DT-5265	READ	TCGA	VPSTS	DEG_SPOP_SBC_1	0.0833
p.V402M	TCGA-G9-7509	PRAD	TCGA	VPSTS	DEG_SPOP_SBC_1	0.0833
p.V402M	DO51338	PRAD	ICGC	VPSTS	DEG_SPOP_SBC_1	0.0833
p.V402M	DO36499	READ	ICGC	VPSTS	DEG_SPOP_SBC_1	0.0833
p.V402M	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.0833
p.V402M	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.0833
p.V402M	SIDM01608	Endometrial Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.0833
p.V402M	ACH-000353	Esophageal Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	0.0833
p.V402M	ACH-000990	Endometrial/Uterine Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	0.0833
p.K387T	DO222637	BTCA	ICGC	VPSTS	DEG_SPOP_SBC_1	0.2778
p.C397Y	SIDM01617	Endometrial Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.2222
p.C397Y	ACH-000994	Endometrial/Uterine Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_SPOP_SBC_1	938:942	VPSTS	SPOP	0.9914	More...
O95665	Neurotensin receptor type 2	DEG_SPOP_SBC_1	240:244	VPSTS	SPOP	0.8867	More...
P24386	Rab proteins geranylgeranyltransferase component A 1	DEG_SPOP_SBC_1	188:192	VPSTS	SPOP	0.9827	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4260:4264	VPSTS	SPOP	0.9795	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_SPOP_SBC_1	2123:2127	VPSTS	SPOP	0.9469	More...
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SPOP_SBC_1	777:781	VPSTS	SPOP	0.9965	More...
Q86WV6	Stimulator of interferon genes protein	DEG_SPOP_SBC_1	351:355	VPSTS	SPOP	0.9975	More...
Q92574	Hamartin	DEG_SPOP_SBC_1	640:644	VPSTS	SPOP	0.9829	More...
Q92772	Cyclin-dependent kinase-like 2	DEG_SPOP_SBC_1	389:393	VPSTS	SPOP	0.9663	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	192:196	VPSTS	SPOP	0.993	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	159:163	VPSTS	SPOP	0.9657	More...
Q8TBF4	Zinc finger CCHC-type and RNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	191:195	VPSTS	SPOP	0.989	More...
P0C6C1	Ankyrin repeat domain-containing protein 34C	DEG_SPOP_SBC_1	426:430	VPSTS	SPOP	0.9869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons