DegronMD

Uniprot ID: P24386

Source protein: Rab proteins geranylgeranyltransferase component A 1

Source gene: CHM

Class: DEG_SPOP_SBC_1

Location: 188:192

E3 ligase: SPOP

DEGRON score: 0.9827

ASA_SCORE: 67.52

COIL: 0.8662

CONS_SCORE: 0.2305

DSS_SCORE: 0.5797

HELIX: 0.0864

FCONS_SCORE: 1.0014

RIG_SCORE: 0.6892

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M196V	TCGA-33-AASJ	LUSC	TCGA	VPSTS	DEG_SPOP_SBC_1	0.2222
p.M196V	DO219131	LUSC	ICGC	VPSTS	DEG_SPOP_SBC_1	0.2222
p.D184G	TCGA-55-8301	LUAD	TCGA	VPSTS	DEG_SPOP_SBC_1	0.2222
p.D184G	DO24682	LUAD	ICGC	VPSTS	DEG_SPOP_SBC_1	0.2222
p.S197G	TCGA-62-A471	LUAD	TCGA	VPSTS	DEG_SPOP_SBC_1	0.1944
p.S197G	DO45347	LUAD	ICGC	VPSTS	DEG_SPOP_SBC_1	0.1944
p.M196I	TCGA-66-2734	LUSC	TCGA	VPSTS	DEG_SPOP_SBC_1	0.2222
p.M196I	DO26430	LUSC	ICGC	VPSTS	DEG_SPOP_SBC_1	0.2222
p.D195E	DO229019	LICA	ICGC	VPSTS	DEG_SPOP_SBC_1	0.25
p.D195E	DO229029	LICA	ICGC	VPSTS	DEG_SPOP_SBC_1	0.25
p.P189T	SIDM00554	Ovarian Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.5919
p.P189T	ACH-000524	Ovarian Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	0.5919
p.P189T	KURAMOCHI	ovary	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_SPOP_SBC_1	938:942	VPSTS	SPOP	0.9914	More...
O95665	Neurotensin receptor type 2	DEG_SPOP_SBC_1	240:244	VPSTS	SPOP	0.8867	More...
P24386	Rab proteins geranylgeranyltransferase component A 1	DEG_SPOP_SBC_1	188:192	VPSTS	SPOP	0.9827	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4260:4264	VPSTS	SPOP	0.9795	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_SPOP_SBC_1	2123:2127	VPSTS	SPOP	0.9469	More...
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SPOP_SBC_1	777:781	VPSTS	SPOP	0.9965	More...
Q86WV6	Stimulator of interferon genes protein	DEG_SPOP_SBC_1	351:355	VPSTS	SPOP	0.9975	More...
Q92574	Hamartin	DEG_SPOP_SBC_1	640:644	VPSTS	SPOP	0.9829	More...
Q92772	Cyclin-dependent kinase-like 2	DEG_SPOP_SBC_1	389:393	VPSTS	SPOP	0.9663	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	192:196	VPSTS	SPOP	0.993	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	159:163	VPSTS	SPOP	0.9657	More...
Q8TBF4	Zinc finger CCHC-type and RNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	191:195	VPSTS	SPOP	0.989	More...
P0C6C1	Ankyrin repeat domain-containing protein 34C	DEG_SPOP_SBC_1	426:430	VPSTS	SPOP	0.9869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons