DegronMD

Uniprot ID: Q92574

Source protein: Hamartin

Source gene: TSC1

Class: DEG_SPOP_SBC_1

Location: 640:644

E3 ligase: SPOP

DEGRON score: 0.9829

ASA_SCORE: 61.2

COIL: 0.904

CONS_SCORE: 0.6198

DSS_SCORE: 0.6224

HELIX: 0.0316

FCONS_SCORE: 1.0081

RIG_SCORE: 0.6619

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E636K	TCGA-2W-A8YY	CESC	TCGA	VPSTS	DEG_SPOP_SBC_1	0.2222
p.E636K	DO223732	CESC	ICGC	VPSTS	DEG_SPOP_SBC_1	0.2222
p.V640M	DO228253	MALY	ICGC	VPSTS	DEG_SPOP_SBC_1	0.7208
p.Q654E	SIDM00367	Small Cell Lung Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.0556
p.Q654E	SIDM00553	Acute Myeloid Leukemia	GDSC	VPSTS	DEG_SPOP_SBC_1	0.0556
p.Q654E	SIDM00383	Gastric Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.0556
p.Q654E	SIDM00024	Non-Cancerous	GDSC	VPSTS	DEG_SPOP_SBC_1	0.0556
p.Q654E	SIDM00579	Neuroblastoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.0556
p.Q654E	SIDM01442	Glioma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.0556
p.M646V	SIDM00694	Other Solid Cancers	GDSC	VPSTS	DEG_SPOP_SBC_1	0.2778
p.M646V	HUTU-80	small_intestine	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.2778
p.G639V	ACH-001029	Bone Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	0.3056
p.G639V	ACH-001034	Bone Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	0.3056
p.I637F	TE-12	oesophagus	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.25
p.L645F	KON	upper_aerodigestive_tract	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.3056
p.R641Q	8505C	thyroid	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.7329
p.M645V	HUTU-80	small_intestine	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.3056
p.G630D	GP5d	large_intestine	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_SPOP_SBC_1	938:942	VPSTS	SPOP	0.9914	More...
O95665	Neurotensin receptor type 2	DEG_SPOP_SBC_1	240:244	VPSTS	SPOP	0.8867	More...
P24386	Rab proteins geranylgeranyltransferase component A 1	DEG_SPOP_SBC_1	188:192	VPSTS	SPOP	0.9827	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4260:4264	VPSTS	SPOP	0.9795	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_SPOP_SBC_1	2123:2127	VPSTS	SPOP	0.9469	More...
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SPOP_SBC_1	777:781	VPSTS	SPOP	0.9965	More...
Q86WV6	Stimulator of interferon genes protein	DEG_SPOP_SBC_1	351:355	VPSTS	SPOP	0.9975	More...
Q92574	Hamartin	DEG_SPOP_SBC_1	640:644	VPSTS	SPOP	0.9829	More...
Q92772	Cyclin-dependent kinase-like 2	DEG_SPOP_SBC_1	389:393	VPSTS	SPOP	0.9663	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	192:196	VPSTS	SPOP	0.993	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	159:163	VPSTS	SPOP	0.9657	More...
Q8TBF4	Zinc finger CCHC-type and RNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	191:195	VPSTS	SPOP	0.989	More...
P0C6C1	Ankyrin repeat domain-containing protein 34C	DEG_SPOP_SBC_1	426:430	VPSTS	SPOP	0.9869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons